Discovery of a Flexible Triazolylbutanoic Acid as a Highly Potent Uric Acid Transporter 1 (URAT1) Inhibitor

In order to systematically explore and understand the structure–activity relationship (SAR) of a lesinurad-based hit (1c) derived from the replacement of the S atom in lesinurad with CH(2), 18 compounds (1a–1r) were designed, synthesized and subjected to in vitro URAT1 inhibitory assay. The SAR expl...

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Detalles Bibliográficos
Autores principales: Tian, He, Liu, Wei, Zhou, Zhixing, Shang, Qian, Liu, Yuqiang, Xie, Yafei, Liu, Changying, Xu, Weiren, Tang, Lida, Wang, Jianwu, Zhao, Guilong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274368/
https://www.ncbi.nlm.nih.gov/pubmed/27854343
http://dx.doi.org/10.3390/molecules21111543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274368/
https://www.ncbi.nlm.nih.gov/pubmed/27854343
http://dx.doi.org/10.3390/molecules21111543

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