Novel Anthranilamide-Based FXa Inhibitors: Drug Design, Synthesis and Biological Evaluation

Factor Xa (FXa) plays a significant role in the blood coagulation cascade and it has become a promising target for anticoagulation drugs. Three oral direct FXa inhibitors have been approved by the FDA for treating thrombotic diseases. By structure-activity relationship (SAR) analysis upon these FXa...

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Detalles Bibliográficos
Autores principales: Wang, Wenzhi, Yuan, Jing, Fu, Xiaoli, Meng, Fancui, Zhang, Shijun, Xu, Weiren, Xu, Yongnan, Huang, Changjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274369/
https://www.ncbi.nlm.nih.gov/pubmed/27089317
http://dx.doi.org/10.3390/molecules21040491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274369/
https://www.ncbi.nlm.nih.gov/pubmed/27089317
http://dx.doi.org/10.3390/molecules21040491

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