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Secondary Metabolites from the Deep-Sea Derived Fungus Acaromyces ingoldii FS121

Activity-guided isolation of the fermentation broth of the deep-sea derived fungus Acaromyces ingoldii FS121, which was obtained from the China South Sea, yielded a new naphtha-[2,3-b]pyrandione analogue, acaromycin A (1) and a new thiazole analogue, acaromyester A (2), as well as the known compound...

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Autores principales: Gao, Xiao-Wei, Liu, Hong-Xin, Sun, Zhang-Hua, Chen, Yu-Chan, Tan, Yu-Zhi, Zhang, Wei-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274379/
http://dx.doi.org/10.3390/molecules21040371
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author Gao, Xiao-Wei
Liu, Hong-Xin
Sun, Zhang-Hua
Chen, Yu-Chan
Tan, Yu-Zhi
Zhang, Wei-Min
author_facet Gao, Xiao-Wei
Liu, Hong-Xin
Sun, Zhang-Hua
Chen, Yu-Chan
Tan, Yu-Zhi
Zhang, Wei-Min
author_sort Gao, Xiao-Wei
collection PubMed
description Activity-guided isolation of the fermentation broth of the deep-sea derived fungus Acaromyces ingoldii FS121, which was obtained from the China South Sea, yielded a new naphtha-[2,3-b]pyrandione analogue, acaromycin A (1) and a new thiazole analogue, acaromyester A (2), as well as the known compound (+)-cryptosporin (3). Their structures, including absolute configurations, were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) spectra. Compounds 1–3 were evaluated for in vitro growth inhibitory activities against four tumor cell lines (MCF-7, NCI-H460, SF-268 and HepG-2), wherein compounds 1 and 3 exhibited considerable growth inhibitory effects, with IC(50) values less than 10 µM.
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spelling pubmed-62743792018-12-28 Secondary Metabolites from the Deep-Sea Derived Fungus Acaromyces ingoldii FS121 Gao, Xiao-Wei Liu, Hong-Xin Sun, Zhang-Hua Chen, Yu-Chan Tan, Yu-Zhi Zhang, Wei-Min Molecules Communication Activity-guided isolation of the fermentation broth of the deep-sea derived fungus Acaromyces ingoldii FS121, which was obtained from the China South Sea, yielded a new naphtha-[2,3-b]pyrandione analogue, acaromycin A (1) and a new thiazole analogue, acaromyester A (2), as well as the known compound (+)-cryptosporin (3). Their structures, including absolute configurations, were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) spectra. Compounds 1–3 were evaluated for in vitro growth inhibitory activities against four tumor cell lines (MCF-7, NCI-H460, SF-268 and HepG-2), wherein compounds 1 and 3 exhibited considerable growth inhibitory effects, with IC(50) values less than 10 µM. MDPI 2016-03-29 /pmc/articles/PMC6274379/ http://dx.doi.org/10.3390/molecules21040371 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Gao, Xiao-Wei
Liu, Hong-Xin
Sun, Zhang-Hua
Chen, Yu-Chan
Tan, Yu-Zhi
Zhang, Wei-Min
Secondary Metabolites from the Deep-Sea Derived Fungus Acaromyces ingoldii FS121
title Secondary Metabolites from the Deep-Sea Derived Fungus Acaromyces ingoldii FS121
title_full Secondary Metabolites from the Deep-Sea Derived Fungus Acaromyces ingoldii FS121
title_fullStr Secondary Metabolites from the Deep-Sea Derived Fungus Acaromyces ingoldii FS121
title_full_unstemmed Secondary Metabolites from the Deep-Sea Derived Fungus Acaromyces ingoldii FS121
title_short Secondary Metabolites from the Deep-Sea Derived Fungus Acaromyces ingoldii FS121
title_sort secondary metabolites from the deep-sea derived fungus acaromyces ingoldii fs121
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274379/
http://dx.doi.org/10.3390/molecules21040371
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