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Secondary Metabolites from the Deep-Sea Derived Fungus Acaromyces ingoldii FS121
Activity-guided isolation of the fermentation broth of the deep-sea derived fungus Acaromyces ingoldii FS121, which was obtained from the China South Sea, yielded a new naphtha-[2,3-b]pyrandione analogue, acaromycin A (1) and a new thiazole analogue, acaromyester A (2), as well as the known compound...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274379/ http://dx.doi.org/10.3390/molecules21040371 |
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author | Gao, Xiao-Wei Liu, Hong-Xin Sun, Zhang-Hua Chen, Yu-Chan Tan, Yu-Zhi Zhang, Wei-Min |
author_facet | Gao, Xiao-Wei Liu, Hong-Xin Sun, Zhang-Hua Chen, Yu-Chan Tan, Yu-Zhi Zhang, Wei-Min |
author_sort | Gao, Xiao-Wei |
collection | PubMed |
description | Activity-guided isolation of the fermentation broth of the deep-sea derived fungus Acaromyces ingoldii FS121, which was obtained from the China South Sea, yielded a new naphtha-[2,3-b]pyrandione analogue, acaromycin A (1) and a new thiazole analogue, acaromyester A (2), as well as the known compound (+)-cryptosporin (3). Their structures, including absolute configurations, were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) spectra. Compounds 1–3 were evaluated for in vitro growth inhibitory activities against four tumor cell lines (MCF-7, NCI-H460, SF-268 and HepG-2), wherein compounds 1 and 3 exhibited considerable growth inhibitory effects, with IC(50) values less than 10 µM. |
format | Online Article Text |
id | pubmed-6274379 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62743792018-12-28 Secondary Metabolites from the Deep-Sea Derived Fungus Acaromyces ingoldii FS121 Gao, Xiao-Wei Liu, Hong-Xin Sun, Zhang-Hua Chen, Yu-Chan Tan, Yu-Zhi Zhang, Wei-Min Molecules Communication Activity-guided isolation of the fermentation broth of the deep-sea derived fungus Acaromyces ingoldii FS121, which was obtained from the China South Sea, yielded a new naphtha-[2,3-b]pyrandione analogue, acaromycin A (1) and a new thiazole analogue, acaromyester A (2), as well as the known compound (+)-cryptosporin (3). Their structures, including absolute configurations, were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) spectra. Compounds 1–3 were evaluated for in vitro growth inhibitory activities against four tumor cell lines (MCF-7, NCI-H460, SF-268 and HepG-2), wherein compounds 1 and 3 exhibited considerable growth inhibitory effects, with IC(50) values less than 10 µM. MDPI 2016-03-29 /pmc/articles/PMC6274379/ http://dx.doi.org/10.3390/molecules21040371 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Gao, Xiao-Wei Liu, Hong-Xin Sun, Zhang-Hua Chen, Yu-Chan Tan, Yu-Zhi Zhang, Wei-Min Secondary Metabolites from the Deep-Sea Derived Fungus Acaromyces ingoldii FS121 |
title | Secondary Metabolites from the Deep-Sea Derived Fungus Acaromyces ingoldii FS121 |
title_full | Secondary Metabolites from the Deep-Sea Derived Fungus Acaromyces ingoldii FS121 |
title_fullStr | Secondary Metabolites from the Deep-Sea Derived Fungus Acaromyces ingoldii FS121 |
title_full_unstemmed | Secondary Metabolites from the Deep-Sea Derived Fungus Acaromyces ingoldii FS121 |
title_short | Secondary Metabolites from the Deep-Sea Derived Fungus Acaromyces ingoldii FS121 |
title_sort | secondary metabolites from the deep-sea derived fungus acaromyces ingoldii fs121 |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274379/ http://dx.doi.org/10.3390/molecules21040371 |
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