Cargando…

Deoxyelephantopin from Elephantopus scaber Inhibits HCT116 Human Colorectal Carcinoma Cell Growth through Apoptosis and Cell Cycle Arrest

Deoxyelephantopin (DET), one of the major sesquiterpene lactones derived from Elephantopus scaber was reported to possess numerous pharmacological functions. This study aimed to assess the apoptosis inducing effects and cell cycle arrest by DET followed by elucidation of the mechanisms underlying ce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chan, Chim Kei, Chan, Gomathi, Awang, Khalijah, Abdul Kadir, Habsah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274388/ https://www.ncbi.nlm.nih.gov/pubmed/27007366 http://dx.doi.org/10.3390/molecules21030385

Ejemplares similares

Anti-neuroinflammatory Activity of Elephantopus scaber L. via Activation of Nrf2/HO-1 Signaling and Inhibition of p38 MAPK Pathway in LPS-Induced Microglia BV-2 Cells
por: Chan, Chim-Kei, et al.
Publicado: (2017)

Antioxidant and Wound Healing Activity of Polyherbal Fractions of Clinacanthus nutans and Elephantopus scaber
por: Aslam, Muhammad Shahzad, et al.
Publicado: (2016)

ANTIBACTERIAL STUDIES ON LEAF EXTRACT OF ELEPHANTOPUS SCABER Linn
por: Kumar, S. Suresh, et al.
Publicado: (2004)

Sesquiterpene Lactone Deoxyelephantopin Isolated from Elephantopus scaber and Its Derivative DETD-35 Suppress BRAF(V600E) Mutant Melanoma Lung Metastasis in Mice
por: Cvetanova, Biljana, et al.
Publicado: (2021)

Hepatoprotective Activity of Elephantopus scaber on Alcohol-Induced Liver Damage in Mice
por: Ho, Wan Yong, et al.
Publicado: (2012)

Evaluation of antiasthmatic activity of ethanolic extract of Elephantopus scaber L. leaves
por: Sagar, Rakesh, et al.
Publicado: (2012)

The Effect of Elephantopus scaber L. on Liver Regeneration after Partial Hepatectomy
por: Tsai, Chin-Chuan, et al.
Publicado: (2013)

Hypolipidemic and Renal Functionality Potentials of the Hexane Extract Fractions of Elephantopus Scaber Linn
por: Daisy, P., et al.
Publicado: (2010)

Bioactivities of Compounds from Elephantopus scaber, an Ethnomedicinal Plant from Southwest China
por: Wang, Jianjun, et al.
Publicado: (2014)

Retracted: The Effect of Elephantopus scaber L. on Liver Regeneration after Partial Hepatectomy
por: and Alternative Medicine, Evidence-Based Complementary
Publicado: (2017)

Isodeoxyelephantopin from Elephantopus scaber (Didancao) induces cell cycle arrest and caspase-3-mediated apoptosis in breast carcinoma T47D cells and lung carcinoma A549 cells
por: Kabeer, Farha Arakkaveettil, et al.
Publicado: (2014)

Synergistic Cytotoxicity between Elephantopus scaber and Tamoxifen on MCF-7-Derived Multicellular Tumor Spheroid
por: Ho, Wan Yong, et al.
Publicado: (2021)

In vitro evaluation of anticancer potentials of lupeol isolated from Elephantopus scaber L. on MCF-7 cell line
por: Pitchai, Daisy, et al.
Publicado: (2014)

Dietary Supplementation With Didancao (Elephantopus scaber L.) Improves Meat Quality and Intestinal Development in Jiaji Ducks
por: Hu, Chengjun, et al.
Publicado: (2021)

The complete chloroplast genome of Elephantopus scaber L. (Vernonioideae, Asteraceae), a useful ethnomedicinal plant in asia
por: Nguyen, Pham Anh Thi, et al.
Publicado: (2023)

The enriched fraction of Elephantopus scaber Triggers apoptosis and inhibits multi-drug resistance transporters in human epithelial cancer cells
por: Beeran, Asmy Appadath, et al.
Publicado: (2015)

Effects of 17-allylamino-17-demethoxygeldanamycin on the induction of apoptosis and cell cycle arrest in HCT-116 cells
por: Zhao, Xuerong, et al.
Publicado: (2017)

A Novel Terpenoid from Elephantopus Scaber – Antibacterial Activity on Staphylococcus Aureus: A Substantiate Computational Approach
por: Daisy, P., et al.
Publicado: (2008)

Berberine Inhibits Telomerase Activity and Induces Cell Cycle Arrest and Telomere Erosion in Colorectal Cancer Cell Line, HCT 116
por: Samad, Muhammad Azizan, et al.
Publicado: (2021)

Luteolin Shifts Oxaliplatin-Induced Cell Cycle Arrest at G(0)/G(1) to Apoptosis in HCT116 Human Colorectal Carcinoma Cells
por: Jang, Chan Ho, et al.
Publicado: (2019)

Mitigation of H(2)O(2)-Induced Mitochondrial-Mediated Apoptosis in NG108-15 Cells by Novel Mesuagenin C from Mesua kunstleri (King) Kosterm
por: Chan, Gomathi, et al.
Publicado: (2012)

Effect of metformin on irinotecan-induced cell cycle arrest in colorectal cancer cell lines HCT116 and SW480
por: Khader, Esra’a I., et al.
Publicado: (2021)

Lentinan-functionalized selenium nanoparticles induce apoptosis and cell cycle arrest in human colon carcinoma HCT-116 cells
por: Gao, Xiong, et al.
Publicado: (2022)

Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells
por: Sun, Ya-Sai, et al.
Publicado: (2022)

Sesquiterpene Lactones Isolated from Elephantopus scaber L. Inhibits Human Lymphocyte Proliferation and the Growth of Tumour Cell Lines and Induces Apoptosis In Vitro
por: Geetha, B. S., et al.
Publicado: (2012)

Scabertopin Derived from Elephantopus scaber L. Mediates Necroptosis by Inducing Reactive Oxygen Species Production in Bladder Cancer In Vitro
por: Gao, Yuanhui, et al.
Publicado: (2022)

MHY2245, a Sirtuin Inhibitor, Induces Cell Cycle Arrest and Apoptosis in HCT116 Human Colorectal Cancer Cells
por: Kang, Yong Jung, et al.
Publicado: (2022)

Structural Properties of Polyphenols Causing Cell Cycle Arrest at G1 Phase in HCT116 Human Colorectal Cancer Cell Lines
por: Shin, Soon Young, et al.
Publicado: (2013)

Induction of p53-Independent Apoptosis and G1 Cell Cycle Arrest by Fucoidan in HCT116 Human Colorectal Carcinoma Cells
por: Park, Hye Young, et al.
Publicado: (2017)

Hormone-balancing and protective effect of combined extract of Sauropus androgynus and Elephantopus scaber against Escherichia coli-induced renal and hepatic necrosis in pregnant mice
por: Christina, Yuyun Ika, et al.
Publicado: (2021)

Molecular mechanisms of anticancer activity of deoxyelephantopin in cancer cells
por: Kabeer, Farha Arakkaveettil, et al.
Publicado: (2017)

Novel SIRT Inhibitor, MHY2256, Induces Cell Cycle Arrest, Apoptosis, and Autophagic Cell Death in HCT116 Human Colorectal Cancer Cells
por: Kim, Min Jeong, et al.
Publicado: (2020)

Aqueous Fraction of Nephelium ramboutan-ake Rind Induces Mitochondrial-Mediated Apoptosis in HT-29 Human Colorectal Adenocarcinoma Cells
por: Chan, Chim Kei, et al.
Publicado: (2012)

In Vitro Evaluation of Chemically Analyzed Hypericum Triquetrifolium Extract Efficacy in Apoptosis Induction and Cell Cycle Arrest of the HCT-116 Colon Cancer Cell Line
por: Mahajna, Shahinaz, et al.
Publicado: (2019)

The combination of Elephantopus scaber and Sauropus androgynus promotes erythroid lineages and modulates follicle-stimulating hormone and luteinizing hormone levels in pregnant mice infected with Escherichia coli
por: Djati, Muhammad Sasmito, et al.
Publicado: (2021)

Raddeanin A Induces Apoptosis and Cycle Arrest in Human HCT116 Cells through PI3K/AKT Pathway Regulation In Vitro and In Vivo
por: Meng, Chunqin, et al.
Publicado: (2019)

Divergent synthesis and identification of the cellular targets of deoxyelephantopins
por: Lagoutte, Roman, et al.
Publicado: (2016)

Intra-Tumoral Heterogeneity in Metastatic Potential and Survival Signaling between Iso-Clonal HCT116 and HCT116b Human Colon Carcinoma Cell Lines
por: Chowdhury, Sanjib, et al.
Publicado: (2013)

Resistin and Visfatin Expression in HCT-116 Colorectal Cancer Cell Line
por: Ghaemmaghami, Sara, et al.
Publicado: (2013)

Procaine Induces Epigenetic Changes in HCT116 Colon Cancer Cells
por: Sabit, Hussein, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_nuluff0m656tfqnfaesq4ljksu