An Unusual Stress Metabolite from a Hydrothermal Vent Fungus Aspergillus sp. WU 243 Induced by Cobalt

A novel hybrid polyketide-terpenoid, aspergstressin (1), possessing a unique fused polycyclic structure, was induced from culture broth of strain Aspergillus sp. WU 243 by cobalt ion stimulation. The strain was isolated from the digestive gland of Xenograpsus testudinatus, a unique type of crab whic...

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Detalles Bibliográficos
Autores principales: Ding, Chihong, Wu, Xiaodan, Auckloo, Bibi Nazia, Chen, Chen-Tung Arthur, Ye, Ying, Wang, Kuiwu, Wu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274401/
https://www.ncbi.nlm.nih.gov/pubmed/26784166
http://dx.doi.org/10.3390/molecules21010105
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author Ding, Chihong
Wu, Xiaodan
Auckloo, Bibi Nazia
Chen, Chen-Tung Arthur
Ye, Ying
Wang, Kuiwu
Wu, Bin
author_facet Ding, Chihong
Wu, Xiaodan
Auckloo, Bibi Nazia
Chen, Chen-Tung Arthur
Ye, Ying
Wang, Kuiwu
Wu, Bin
author_sort Ding, Chihong
collection PubMed
description A novel hybrid polyketide-terpenoid, aspergstressin (1), possessing a unique fused polycyclic structure, was induced from culture broth of strain Aspergillus sp. WU 243 by cobalt ion stimulation. The strain was isolated from the digestive gland of Xenograpsus testudinatus, a unique type of crab which dwells in the Kueishantao hydrothermal vents off Taiwan. The chemical structure and relative configuration of the stress metabolite were established by spectroscopic means. Aspergillus sp. WU 243 produced aspergstressin (1) only under cobalt stressed culture conditions. The results show that stress-driven discovery of new natural products from hydrothermal vent fungi is an effective strategy to unveil the untapped reservoir of small molecules from species found in the hydrothermal vent environment.
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spelling pubmed-62744012018-12-28 An Unusual Stress Metabolite from a Hydrothermal Vent Fungus Aspergillus sp. WU 243 Induced by Cobalt Ding, Chihong Wu, Xiaodan Auckloo, Bibi Nazia Chen, Chen-Tung Arthur Ye, Ying Wang, Kuiwu Wu, Bin Molecules Article A novel hybrid polyketide-terpenoid, aspergstressin (1), possessing a unique fused polycyclic structure, was induced from culture broth of strain Aspergillus sp. WU 243 by cobalt ion stimulation. The strain was isolated from the digestive gland of Xenograpsus testudinatus, a unique type of crab which dwells in the Kueishantao hydrothermal vents off Taiwan. The chemical structure and relative configuration of the stress metabolite were established by spectroscopic means. Aspergillus sp. WU 243 produced aspergstressin (1) only under cobalt stressed culture conditions. The results show that stress-driven discovery of new natural products from hydrothermal vent fungi is an effective strategy to unveil the untapped reservoir of small molecules from species found in the hydrothermal vent environment. MDPI 2016-01-16 /pmc/articles/PMC6274401/ /pubmed/26784166 http://dx.doi.org/10.3390/molecules21010105 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ding, Chihong
Wu, Xiaodan
Auckloo, Bibi Nazia
Chen, Chen-Tung Arthur
Ye, Ying
Wang, Kuiwu
Wu, Bin
An Unusual Stress Metabolite from a Hydrothermal Vent Fungus Aspergillus sp. WU 243 Induced by Cobalt
title An Unusual Stress Metabolite from a Hydrothermal Vent Fungus Aspergillus sp. WU 243 Induced by Cobalt
title_full An Unusual Stress Metabolite from a Hydrothermal Vent Fungus Aspergillus sp. WU 243 Induced by Cobalt
title_fullStr An Unusual Stress Metabolite from a Hydrothermal Vent Fungus Aspergillus sp. WU 243 Induced by Cobalt
title_full_unstemmed An Unusual Stress Metabolite from a Hydrothermal Vent Fungus Aspergillus sp. WU 243 Induced by Cobalt
title_short An Unusual Stress Metabolite from a Hydrothermal Vent Fungus Aspergillus sp. WU 243 Induced by Cobalt
title_sort unusual stress metabolite from a hydrothermal vent fungus aspergillus sp. wu 243 induced by cobalt
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274401/
https://www.ncbi.nlm.nih.gov/pubmed/26784166
http://dx.doi.org/10.3390/molecules21010105
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