In-Vitro Anticancer Evaluation of Some Novel Thioureido-Benzensulfonamide Derivatives

A novel series of sulfonamide derivatives (14 compounds) bearing thiourea moieties were efficiently synthesized and evaluated for their possible in vitro anticancer activity against four human tumor cell lines. The results indicated that compound 6 was the most potent, showing effectiveness on all t...

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Autores principales: Ghorab, Mostafa M., Alsaid, Mansour S., Al-Dosari, Mohammed S., El-Gazzar, Marwa G., Arbab, Ahmed H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274422/
https://www.ncbi.nlm.nih.gov/pubmed/27023509
http://dx.doi.org/10.3390/molecules21040409
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author Ghorab, Mostafa M.
Alsaid, Mansour S.
Al-Dosari, Mohammed S.
El-Gazzar, Marwa G.
Arbab, Ahmed H.
author_facet Ghorab, Mostafa M.
Alsaid, Mansour S.
Al-Dosari, Mohammed S.
El-Gazzar, Marwa G.
Arbab, Ahmed H.
author_sort Ghorab, Mostafa M.
collection PubMed
description A novel series of sulfonamide derivatives (14 compounds) bearing thiourea moieties were efficiently synthesized and evaluated for their possible in vitro anticancer activity against four human tumor cell lines. The results indicated that compound 6 was the most potent, showing effectiveness on all the tested cell lines. Compounds 7 and 10 also showed promising results.
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spelling pubmed-62744222018-12-28 In-Vitro Anticancer Evaluation of Some Novel Thioureido-Benzensulfonamide Derivatives Ghorab, Mostafa M. Alsaid, Mansour S. Al-Dosari, Mohammed S. El-Gazzar, Marwa G. Arbab, Ahmed H. Molecules Article A novel series of sulfonamide derivatives (14 compounds) bearing thiourea moieties were efficiently synthesized and evaluated for their possible in vitro anticancer activity against four human tumor cell lines. The results indicated that compound 6 was the most potent, showing effectiveness on all the tested cell lines. Compounds 7 and 10 also showed promising results. MDPI 2016-03-25 /pmc/articles/PMC6274422/ /pubmed/27023509 http://dx.doi.org/10.3390/molecules21040409 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ghorab, Mostafa M.
Alsaid, Mansour S.
Al-Dosari, Mohammed S.
El-Gazzar, Marwa G.
Arbab, Ahmed H.
In-Vitro Anticancer Evaluation of Some Novel Thioureido-Benzensulfonamide Derivatives
title In-Vitro Anticancer Evaluation of Some Novel Thioureido-Benzensulfonamide Derivatives
title_full In-Vitro Anticancer Evaluation of Some Novel Thioureido-Benzensulfonamide Derivatives
title_fullStr In-Vitro Anticancer Evaluation of Some Novel Thioureido-Benzensulfonamide Derivatives
title_full_unstemmed In-Vitro Anticancer Evaluation of Some Novel Thioureido-Benzensulfonamide Derivatives
title_short In-Vitro Anticancer Evaluation of Some Novel Thioureido-Benzensulfonamide Derivatives
title_sort in-vitro anticancer evaluation of some novel thioureido-benzensulfonamide derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274422/
https://www.ncbi.nlm.nih.gov/pubmed/27023509
http://dx.doi.org/10.3390/molecules21040409
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