Deprotection Reagents in Fmoc Solid Phase Peptide Synthesis: Moving Away from Piperidine?

The deprotection step is crucial in order to secure a good quality product in Fmoc solid phase peptide synthesis. 9-Fluorenylmethoxycarbonyl (Fmoc) removal is achieved by a two-step mechanism reaction favored by the use of cyclic secondary amines; however, the efficiency of the reaction could be aff...

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Detalles Bibliográficos
Autores principales: Luna, Omar F., Gomez, Johana, Cárdenas, Constanza, Albericio, Fernando, Marshall, Sergio H., Guzmán, Fanny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274427/
https://www.ncbi.nlm.nih.gov/pubmed/27854291
http://dx.doi.org/10.3390/molecules21111542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274427/
https://www.ncbi.nlm.nih.gov/pubmed/27854291
http://dx.doi.org/10.3390/molecules21111542

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