Cargando…

Deprotection Reagents in Fmoc Solid Phase Peptide Synthesis: Moving Away from Piperidine?

The deprotection step is crucial in order to secure a good quality product in Fmoc solid phase peptide synthesis. 9-Fluorenylmethoxycarbonyl (Fmoc) removal is achieved by a two-step mechanism reaction favored by the use of cyclic secondary amines; however, the efficiency of the reaction could be aff...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luna, Omar F., Gomez, Johana, Cárdenas, Constanza, Albericio, Fernando, Marshall, Sergio H., Guzmán, Fanny
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274427/ https://www.ncbi.nlm.nih.gov/pubmed/27854291 http://dx.doi.org/10.3390/molecules21111542

Ejemplares similares

Tea Bags for Fmoc Solid-Phase Peptide Synthesis: An Example of Circular Economy
por: Guzmán, Fanny, et al.
Publicado: (2021)

Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis
por: Personne, Hippolyte, et al.
Publicado: (2023)

S-Fluorenylmethyl protection of the cysteine side chain upon N(α)-Fmoc deprotection
por: Wehner, Johannes W, et al.
Publicado: (2012)

Protocol for Facile Synthesis of Fmoc-N-Me-AA-OH Using 2-CTC Resin as Temporary and Reusable Protecting Group
por: Román, Tanya, et al.
Publicado: (2023)

Cysteine Pseudoprolines for Thiol Protection and Peptide Macrocyclization Enhancement in Fmoc-Based Solid-Phase Peptide Synthesis
por: Postma, Tobias M., et al.
Publicado: (2014)

Advances in Fmoc solid‐phase peptide synthesis
por: Behrendt, Raymond, et al.
Publicado: (2016)

Methionine-Containing Peptides: Avoiding Secondary Reactions in the Final Global Deprotection
por: Nandhini, K. P., et al.
Publicado: (2023)

Scope and Limitations of γ-Valerolactone (GVL) as a Green Solvent to be Used with Base for Fmoc Removal in Solid Phase Peptide Synthesis
por: Kumar, Ashish, et al.
Publicado: (2019)

Predicting the Success of Fmoc-Based Peptide Synthesis
por: Gutman, Ilanit, et al.
Publicado: (2022)

Chemical Synthesis and Functional Analysis of VarvA Cyclotide
por: Álvarez, Claudio A., et al.
Publicado: (2018)

Solid State Deprotection of Acetals and Thioacetals Using Benzyltriphenylphosphonium Peroxymonosulfate
por: Hajipour, Abdol Reza, et al.
Publicado: (2002)

Identification of Antimicrobial Peptides from the Microalgae Tetraselmis suecica (Kylin) Butcher and Bactericidal Activity Improvement
por: Guzmán, Fanny, et al.
Publicado: (2019)

Arginine Homopeptide of 11 Residues as a Model of Cell-Penetrating Peptides in the Interaction with Bacterial Membranes
por: Aróstica, Mónica, et al.
Publicado: (2022)

Evaluation of acid-labile S-protecting groups to prevent Cys racemization in Fmoc solid-phase peptide synthesis
por: Hibino, Hajime, et al.
Publicado: (2014)

Optimized Fmoc-Removal Strategy to Suppress the Traceless and Conventional Diketopiperazine Formation in Solid-Phase Peptide Synthesis
por: Yang, Yi, et al.
Publicado: (2022)

Preparation and Application of an Inexpensive α-Formylglycine Building Block Compatible with Fmoc Solid-Phase Peptide Synthesis
por: Yates, Nicholas D. J., et al.
Publicado: (2023)

Immobilized N-Chlorosuccinimide as a Friendly Peptide Disulfide-Forming Reagent
por: Postma, Tobias M., et al.
Publicado: (2014)

Solid-Phase Synthesis of Head to Side-Chain Tyr-Cyclodepsipeptides Through a Cyclative Cleavage From Fmoc-MeDbz/MeNbz-resins
por: Acosta, Gerardo A., et al.
Publicado: (2020)

Improving Fmoc Solid Phase Synthesis of Human Beta Defensin 3
por: Walewska, Aleksandra, et al.
Publicado: (2022)

Computing - moving away from the mainframe
Publicado: (1994)

Convenient and Scalable Synthesis of Fmoc-Protected Peptide Nucleic Acid Backbone
por: Feagin, Trevor A., et al.
Publicado: (2012)

A shelf stable Fmoc hydrazine resin for the synthesis of peptide hydrazides
por: Bird, Michael J., et al.
Publicado: (2022)

Efficient Method for the Concentration Determination of Fmoc Groups Incorporated in the Core-Shell Materials by Fmoc–Glycine
por: Szczepańska, Elżbieta, et al.
Publicado: (2020)

Moving Away from Amyloid Beta to Move on in Alzheimer Research
por: Moreno-Treviño, María G., et al.
Publicado: (2015)

Cyanobacteria and Eukaryotic Microalgae as Emerging Sources of Antibacterial Peptides
por: Rojas, Verónica, et al.
Publicado: (2020)

Crohn’s Strictures—Moving Away from the Knife
por: Stenke, Emily, et al.
Publicado: (2017)

Moving away from zero COVID in China
por: Burki, Talha
Publicado: (2023)

Oxime-Based Carbonates as Useful Reagents for Both N-Protection and Peptide Coupling
por: Jad, Yahya El-Sayed, et al.
Publicado: (2012)

Synthetic Peptides as a Promising Alternative to Control Viral Infections in Atlantic Salmon
por: Cárdenas, Constanza, et al.
Publicado: (2020)

Assessing incomplete deprotection of microarray oligonucleotides in situ
por: Dressman, Holly K., et al.
Publicado: (2006)

Glutathione-Triggered Formation of a Fmoc-Protected Short Peptide-Based Supramolecular Hydrogel
por: Shi, Yang, et al.
Publicado: (2014)

Biosynthesis and Characterization of Cross-Linked Fmoc Peptide-Based Hydrogels for Drug Delivery Applications
por: Chronopoulou, Laura, et al.
Publicado: (2015)

Antimicrobial Activity of an Fmoc-Plantaricin 149 Derivative Peptide against Multidrug-Resistant Bacteria
por: Righetto, Gabriela Marinho, et al.
Publicado: (2023)

Improving 2-Chlorotrityl Chloride (2-CTC) Resin Activation
por: Román, Tanya, et al.
Publicado: (2023)

Computing - moving away from the mainframe by David Williams
Publicado: (1994)

PAINT‐ing Fluorenylmethoxycarbonyl (Fmoc)‐Diphenylalanine Hydrogels
por: Fuentes, Edgar, et al.
Publicado: (2020)

Efficient Deprotection of Phenol Methoxymethyl Ethers Using a Solid Acid Catalyst with Wells-Dawson Structure†
por: Romanelli, G., et al.
Publicado: (2001)

A straightforward method for automated Fmoc-based synthesis of bio-inspired peptide crypto-thioesters
por: Terrier, Victor P., et al.
Publicado: (2016)

Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid
por: Basavalingappa, Vasantha, et al.
Publicado: (2019)

Incorporation of Natural and Recombinant Collagen Proteins within Fmoc-Based Self-Assembling Peptide Hydrogels
por: Vitale, Mattia, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_nuo8cl7rol9inkfaascem5rgf1