Compound Library Screening Identified Cardiac Glycoside Digitoxin as an Effective Growth Inhibitor of Gefitinib-Resistant Non-Small Cell Lung Cancer via Downregulation of α-Tubulin and Inhibition of Microtubule Formation

Non-small-cell lung cancer (NSCLC) dominates over 85% of all lung cancer cases. Epidermal growth factor receptor (EGFR) activating mutation is a common situation in NSCLC. In the clinic, molecular-targeting with Gefitinib as a tyrosine kinase inhibitor (TKI) for EGFR downstream signaling is initiall...

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Detalles Bibliográficos
Autores principales: Zhang, Yi-Ze, Chen, Xi, Fan, Xing-Xing, He, Jian-Xing, Huang, Jun, Xiao, Da-Kai, Zhou, Yan-Ling, Zheng, Sen-You, Xu, Jia-Hui, Yao, Xiao-Jun, Liu, Liang, Leung, Elaine Lai-Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274445/
https://www.ncbi.nlm.nih.gov/pubmed/26999101
http://dx.doi.org/10.3390/molecules21030374

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