Synthesis, Molecular Structure Optimization, and Cytotoxicity Assay of a Novel 2-Acetyl-3-amino-5-[(2-oxopropyl)sulfanyl]-4-cyanothiophene

A novel thiophene-containing compound, 2-acetyl-3-amino-5-[(2-oxopropyl)sulfanyl]-4-cyanothiophene (4) was synthesized by reaction of malononitrile with CS(2) in the presence of K(2)CO(3) under reflux in DMF and the subsequent reaction with chloroacetone followed by cyclization. This compound has be...

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Detalles Bibliográficos
Autores principales: Mabkhot, Yahia N., Aldawsari, Fahad D., Al-Showiman, Salim S., Barakat, Assem, Soliman, Saied M., Choudhary, Muhammad I., Yousuf, Sammer, Ben Hadda, Taibi, Mubarak, Mohammad S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274473/
https://www.ncbi.nlm.nih.gov/pubmed/26891285
http://dx.doi.org/10.3390/molecules21020214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274473/
https://www.ncbi.nlm.nih.gov/pubmed/26891285
http://dx.doi.org/10.3390/molecules21020214

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