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Miracle Fruit (Synsepalum dulcificum) Exhibits as a Novel Anti-Hyperuricaemia Agent

Miracle fruit (Synsepalum dulcificum) belongs to the Sapotaceae family. It can change flavors on taste buds, transforming acidic tastes to sweet. We evaluated various miracle fruit extracts, including water, butanol, ethyl acetate (EA), and hexane fractions, to determine its antioxidant effects. The...

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Autores principales: Shi, Yeu-Ching, Lin, Kai-Sian, Jhai, Yi-Fen, Lee, Bao-Hong, Han, Yifan, Cui, Zhibin, Hsu, Wei-Hsuan, Wu, She-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274476/
https://www.ncbi.nlm.nih.gov/pubmed/26821007
http://dx.doi.org/10.3390/molecules21020140
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author Shi, Yeu-Ching
Lin, Kai-Sian
Jhai, Yi-Fen
Lee, Bao-Hong
Han, Yifan
Cui, Zhibin
Hsu, Wei-Hsuan
Wu, She-Ching
author_facet Shi, Yeu-Ching
Lin, Kai-Sian
Jhai, Yi-Fen
Lee, Bao-Hong
Han, Yifan
Cui, Zhibin
Hsu, Wei-Hsuan
Wu, She-Ching
author_sort Shi, Yeu-Ching
collection PubMed
description Miracle fruit (Synsepalum dulcificum) belongs to the Sapotaceae family. It can change flavors on taste buds, transforming acidic tastes to sweet. We evaluated various miracle fruit extracts, including water, butanol, ethyl acetate (EA), and hexane fractions, to determine its antioxidant effects. These extracts isolated from miracle fruit exerted potential for reduction of uric acid and inhibited xanthine oxidase activity in vitro and in monosodiumurate (MSU)-treated RAW264.7 macrophages. Moreover, we also found that the butanol extracts of miracle fruit attenuated oxonic acid potassium salt-induced hyperuricaemia in ICR mice by lowering serum uric acid levels and activating hepatic xanthine oxidase. These effects were equal to those of allopurinol, suggesting that the butanol extract of miracle fruit could be developed as a novel anti-hyperuricaemia agent or health food.
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spelling pubmed-62744762018-12-28 Miracle Fruit (Synsepalum dulcificum) Exhibits as a Novel Anti-Hyperuricaemia Agent Shi, Yeu-Ching Lin, Kai-Sian Jhai, Yi-Fen Lee, Bao-Hong Han, Yifan Cui, Zhibin Hsu, Wei-Hsuan Wu, She-Ching Molecules Article Miracle fruit (Synsepalum dulcificum) belongs to the Sapotaceae family. It can change flavors on taste buds, transforming acidic tastes to sweet. We evaluated various miracle fruit extracts, including water, butanol, ethyl acetate (EA), and hexane fractions, to determine its antioxidant effects. These extracts isolated from miracle fruit exerted potential for reduction of uric acid and inhibited xanthine oxidase activity in vitro and in monosodiumurate (MSU)-treated RAW264.7 macrophages. Moreover, we also found that the butanol extracts of miracle fruit attenuated oxonic acid potassium salt-induced hyperuricaemia in ICR mice by lowering serum uric acid levels and activating hepatic xanthine oxidase. These effects were equal to those of allopurinol, suggesting that the butanol extract of miracle fruit could be developed as a novel anti-hyperuricaemia agent or health food. MDPI 2016-01-26 /pmc/articles/PMC6274476/ /pubmed/26821007 http://dx.doi.org/10.3390/molecules21020140 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shi, Yeu-Ching
Lin, Kai-Sian
Jhai, Yi-Fen
Lee, Bao-Hong
Han, Yifan
Cui, Zhibin
Hsu, Wei-Hsuan
Wu, She-Ching
Miracle Fruit (Synsepalum dulcificum) Exhibits as a Novel Anti-Hyperuricaemia Agent
title Miracle Fruit (Synsepalum dulcificum) Exhibits as a Novel Anti-Hyperuricaemia Agent
title_full Miracle Fruit (Synsepalum dulcificum) Exhibits as a Novel Anti-Hyperuricaemia Agent
title_fullStr Miracle Fruit (Synsepalum dulcificum) Exhibits as a Novel Anti-Hyperuricaemia Agent
title_full_unstemmed Miracle Fruit (Synsepalum dulcificum) Exhibits as a Novel Anti-Hyperuricaemia Agent
title_short Miracle Fruit (Synsepalum dulcificum) Exhibits as a Novel Anti-Hyperuricaemia Agent
title_sort miracle fruit (synsepalum dulcificum) exhibits as a novel anti-hyperuricaemia agent
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274476/
https://www.ncbi.nlm.nih.gov/pubmed/26821007
http://dx.doi.org/10.3390/molecules21020140
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