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Molecular Docking Optimization in the Context of Multi-Drug Resistant and Sensitive EGFR Mutants

The human Epidermal Growth Factor (EGFR) plays an important role in signaling pathways, such as cell proliferation and migration. Mutations like G719S, L858R, T790M, G719S/T790M or T790M/L858R can alter its conformation, and, therefore, drug responses from lung cancer patients. In this context, cand...

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Detalles Bibliográficos
Autores principales:	García-Godoy, María Jesús, López-Camacho, Esteban, García-Nieto, José, Nebro, Antonio J., Aldana-Montes, José F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274512/ https://www.ncbi.nlm.nih.gov/pubmed/27869781 http://dx.doi.org/10.3390/molecules21111575

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