Chemical Constituents from Flueggea virosa and the Structural Revision of Dehydrochebulic Acid Trimethyl Ester

In an attempt to study the chemical constituents from the twigs and leaves of Flueggea virosa, a new terpenoid, 9(10→20)-abeo-ent-podocarpane, 3β,10α-dihydroxy-12-methoxy-13- methyl-9(10→20)-abeo-ent-podocarpa-6,8,11,13-tetraene (1), as well as five known compounds were characterized. Their structur...

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Autores principales: Chao, Chih-Hua, Lin, Ying-Ju, Cheng, Ju-Chien, Huang, Hui-Chi, Yeh, Yung-Ju, Wu, Tian-Shung, Hwang, Syh-Yuan, Wu, Yang-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274521/
https://www.ncbi.nlm.nih.gov/pubmed/27649134
http://dx.doi.org/10.3390/molecules21091239
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author Chao, Chih-Hua
Lin, Ying-Ju
Cheng, Ju-Chien
Huang, Hui-Chi
Yeh, Yung-Ju
Wu, Tian-Shung
Hwang, Syh-Yuan
Wu, Yang-Chang
author_facet Chao, Chih-Hua
Lin, Ying-Ju
Cheng, Ju-Chien
Huang, Hui-Chi
Yeh, Yung-Ju
Wu, Tian-Shung
Hwang, Syh-Yuan
Wu, Yang-Chang
author_sort Chao, Chih-Hua
collection PubMed
description In an attempt to study the chemical constituents from the twigs and leaves of Flueggea virosa, a new terpenoid, 9(10→20)-abeo-ent-podocarpane, 3β,10α-dihydroxy-12-methoxy-13- methyl-9(10→20)-abeo-ent-podocarpa-6,8,11,13-tetraene (1), as well as five known compounds were characterized. Their structures were elucidated on the basis of spectroscopic analysis. In addition, the structure of dehydrochebulic acid trimethyl ester was revised as (2S,3R)-4E-dehydrochebulic acid trimethyl ester based on a single-crystal X-ray diffraction study. The in vitro anti-hepatitis C virus (anti-HCV) activity and cytotoxicity against Huh7.5 cells for the isolated compounds were evaluated.
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spelling pubmed-62745212018-12-28 Chemical Constituents from Flueggea virosa and the Structural Revision of Dehydrochebulic Acid Trimethyl Ester Chao, Chih-Hua Lin, Ying-Ju Cheng, Ju-Chien Huang, Hui-Chi Yeh, Yung-Ju Wu, Tian-Shung Hwang, Syh-Yuan Wu, Yang-Chang Molecules Article In an attempt to study the chemical constituents from the twigs and leaves of Flueggea virosa, a new terpenoid, 9(10→20)-abeo-ent-podocarpane, 3β,10α-dihydroxy-12-methoxy-13- methyl-9(10→20)-abeo-ent-podocarpa-6,8,11,13-tetraene (1), as well as five known compounds were characterized. Their structures were elucidated on the basis of spectroscopic analysis. In addition, the structure of dehydrochebulic acid trimethyl ester was revised as (2S,3R)-4E-dehydrochebulic acid trimethyl ester based on a single-crystal X-ray diffraction study. The in vitro anti-hepatitis C virus (anti-HCV) activity and cytotoxicity against Huh7.5 cells for the isolated compounds were evaluated. MDPI 2016-09-16 /pmc/articles/PMC6274521/ /pubmed/27649134 http://dx.doi.org/10.3390/molecules21091239 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chao, Chih-Hua
Lin, Ying-Ju
Cheng, Ju-Chien
Huang, Hui-Chi
Yeh, Yung-Ju
Wu, Tian-Shung
Hwang, Syh-Yuan
Wu, Yang-Chang
Chemical Constituents from Flueggea virosa and the Structural Revision of Dehydrochebulic Acid Trimethyl Ester
title Chemical Constituents from Flueggea virosa and the Structural Revision of Dehydrochebulic Acid Trimethyl Ester
title_full Chemical Constituents from Flueggea virosa and the Structural Revision of Dehydrochebulic Acid Trimethyl Ester
title_fullStr Chemical Constituents from Flueggea virosa and the Structural Revision of Dehydrochebulic Acid Trimethyl Ester
title_full_unstemmed Chemical Constituents from Flueggea virosa and the Structural Revision of Dehydrochebulic Acid Trimethyl Ester
title_short Chemical Constituents from Flueggea virosa and the Structural Revision of Dehydrochebulic Acid Trimethyl Ester
title_sort chemical constituents from flueggea virosa and the structural revision of dehydrochebulic acid trimethyl ester
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274521/
https://www.ncbi.nlm.nih.gov/pubmed/27649134
http://dx.doi.org/10.3390/molecules21091239
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