Four New 2-(2-Phenylethyl)chromone Derivatives from Chinese Agarwood Produced via the Whole-Tree Agarwood-Inducing Technique

Four new 2-(2-phenylethyl)chromone derivatives (1–4) were isolated from the EtOH extract of Chinese agarwood produced via the whole-tree agarwood-inducing technique, coming from Aquilaria sinensis (Lour.) Spreng. (Thymelaeaceae). Their structures were elucidated by extensive spectroscopic methods, s...

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Autores principales: Liu, Yang-Yang, Chen, De-Li, Wei, Jian-He, Feng, Jian, Zhang, Zheng, Yang, Yun, Zheng, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274528/
https://www.ncbi.nlm.nih.gov/pubmed/27801808
http://dx.doi.org/10.3390/molecules21111433
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author Liu, Yang-Yang
Chen, De-Li
Wei, Jian-He
Feng, Jian
Zhang, Zheng
Yang, Yun
Zheng, Wei
author_facet Liu, Yang-Yang
Chen, De-Li
Wei, Jian-He
Feng, Jian
Zhang, Zheng
Yang, Yun
Zheng, Wei
author_sort Liu, Yang-Yang
collection PubMed
description Four new 2-(2-phenylethyl)chromone derivatives (1–4) were isolated from the EtOH extract of Chinese agarwood produced via the whole-tree agarwood-inducing technique, coming from Aquilaria sinensis (Lour.) Spreng. (Thymelaeaceae). Their structures were elucidated by extensive spectroscopic methods, such as UV, IR, MS, 1D as well as 2D NMR. All of the isolates were then assessed for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7. Compound 1 exhibited significant inhibitory activity with an IC(50) value of 4.6 μM.
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spelling pubmed-62745282018-12-28 Four New 2-(2-Phenylethyl)chromone Derivatives from Chinese Agarwood Produced via the Whole-Tree Agarwood-Inducing Technique Liu, Yang-Yang Chen, De-Li Wei, Jian-He Feng, Jian Zhang, Zheng Yang, Yun Zheng, Wei Molecules Article Four new 2-(2-phenylethyl)chromone derivatives (1–4) were isolated from the EtOH extract of Chinese agarwood produced via the whole-tree agarwood-inducing technique, coming from Aquilaria sinensis (Lour.) Spreng. (Thymelaeaceae). Their structures were elucidated by extensive spectroscopic methods, such as UV, IR, MS, 1D as well as 2D NMR. All of the isolates were then assessed for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7. Compound 1 exhibited significant inhibitory activity with an IC(50) value of 4.6 μM. MDPI 2016-10-27 /pmc/articles/PMC6274528/ /pubmed/27801808 http://dx.doi.org/10.3390/molecules21111433 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Yang-Yang
Chen, De-Li
Wei, Jian-He
Feng, Jian
Zhang, Zheng
Yang, Yun
Zheng, Wei
Four New 2-(2-Phenylethyl)chromone Derivatives from Chinese Agarwood Produced via the Whole-Tree Agarwood-Inducing Technique
title Four New 2-(2-Phenylethyl)chromone Derivatives from Chinese Agarwood Produced via the Whole-Tree Agarwood-Inducing Technique
title_full Four New 2-(2-Phenylethyl)chromone Derivatives from Chinese Agarwood Produced via the Whole-Tree Agarwood-Inducing Technique
title_fullStr Four New 2-(2-Phenylethyl)chromone Derivatives from Chinese Agarwood Produced via the Whole-Tree Agarwood-Inducing Technique
title_full_unstemmed Four New 2-(2-Phenylethyl)chromone Derivatives from Chinese Agarwood Produced via the Whole-Tree Agarwood-Inducing Technique
title_short Four New 2-(2-Phenylethyl)chromone Derivatives from Chinese Agarwood Produced via the Whole-Tree Agarwood-Inducing Technique
title_sort four new 2-(2-phenylethyl)chromone derivatives from chinese agarwood produced via the whole-tree agarwood-inducing technique
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274528/
https://www.ncbi.nlm.nih.gov/pubmed/27801808
http://dx.doi.org/10.3390/molecules21111433
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