One Pot Single Step Synthesis and Biological Evaluation of Some Novel Bis(1,3,4-thiadiazole) Derivatives as Potential Cytotoxic Agents

A novel series of bis(1,3,4-thiadiazole) derivatives were synthesized in one step methodology with good yields by condensation reaction between bis-hydrazonoyl chloride 1 and various reagents. The structures of the prepared compounds were confirmed by spectral data (IR, NMR, and MS), and elemental a...

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Autores principales: Gomha, Sobhi M., Kheder, Nabila A., Abdelhamid, Abdou O., Mabkhot, Yahia N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274530/
https://www.ncbi.nlm.nih.gov/pubmed/27854300
http://dx.doi.org/10.3390/molecules21111532
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author Gomha, Sobhi M.
Kheder, Nabila A.
Abdelhamid, Abdou O.
Mabkhot, Yahia N.
author_facet Gomha, Sobhi M.
Kheder, Nabila A.
Abdelhamid, Abdou O.
Mabkhot, Yahia N.
author_sort Gomha, Sobhi M.
collection PubMed
description A novel series of bis(1,3,4-thiadiazole) derivatives were synthesized in one step methodology with good yields by condensation reaction between bis-hydrazonoyl chloride 1 and various reagents. The structures of the prepared compounds were confirmed by spectral data (IR, NMR, and MS), and elemental analysis. The anticancer activity against human breast carcinoma (MCF-7) cancer cell lines was evaluated in MTT assay. The results revealed that the bis-thiadiazole derivatives 5c,d, 7b,c and 9c had higher antitumor activity than the standard drug Imatinib.
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spelling pubmed-62745302018-12-28 One Pot Single Step Synthesis and Biological Evaluation of Some Novel Bis(1,3,4-thiadiazole) Derivatives as Potential Cytotoxic Agents Gomha, Sobhi M. Kheder, Nabila A. Abdelhamid, Abdou O. Mabkhot, Yahia N. Molecules Article A novel series of bis(1,3,4-thiadiazole) derivatives were synthesized in one step methodology with good yields by condensation reaction between bis-hydrazonoyl chloride 1 and various reagents. The structures of the prepared compounds were confirmed by spectral data (IR, NMR, and MS), and elemental analysis. The anticancer activity against human breast carcinoma (MCF-7) cancer cell lines was evaluated in MTT assay. The results revealed that the bis-thiadiazole derivatives 5c,d, 7b,c and 9c had higher antitumor activity than the standard drug Imatinib. MDPI 2016-11-15 /pmc/articles/PMC6274530/ /pubmed/27854300 http://dx.doi.org/10.3390/molecules21111532 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gomha, Sobhi M.
Kheder, Nabila A.
Abdelhamid, Abdou O.
Mabkhot, Yahia N.
One Pot Single Step Synthesis and Biological Evaluation of Some Novel Bis(1,3,4-thiadiazole) Derivatives as Potential Cytotoxic Agents
title One Pot Single Step Synthesis and Biological Evaluation of Some Novel Bis(1,3,4-thiadiazole) Derivatives as Potential Cytotoxic Agents
title_full One Pot Single Step Synthesis and Biological Evaluation of Some Novel Bis(1,3,4-thiadiazole) Derivatives as Potential Cytotoxic Agents
title_fullStr One Pot Single Step Synthesis and Biological Evaluation of Some Novel Bis(1,3,4-thiadiazole) Derivatives as Potential Cytotoxic Agents
title_full_unstemmed One Pot Single Step Synthesis and Biological Evaluation of Some Novel Bis(1,3,4-thiadiazole) Derivatives as Potential Cytotoxic Agents
title_short One Pot Single Step Synthesis and Biological Evaluation of Some Novel Bis(1,3,4-thiadiazole) Derivatives as Potential Cytotoxic Agents
title_sort one pot single step synthesis and biological evaluation of some novel bis(1,3,4-thiadiazole) derivatives as potential cytotoxic agents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274530/
https://www.ncbi.nlm.nih.gov/pubmed/27854300
http://dx.doi.org/10.3390/molecules21111532
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