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Imidazole Alkaloids from the South China Sea Sponge Pericharax heteroraphis and Their Cytotoxic and Antiviral Activities

Marine sponges continue to serve as a rich source of alkaloids possessing interesting biological activities and often exhibiting unique structural frameworks. In the current study, chemical investigation on the marine sponge Pericharax heteroraphis collected from the South China Sea yielded one new...

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Autores principales: Gong, Kai-Kai, Tang, Xu-Li, Liu, Yi-Sheng, Li, Ping-Lin, Li, Guo-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274532/
https://www.ncbi.nlm.nih.gov/pubmed/26821008
http://dx.doi.org/10.3390/molecules21020150
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author Gong, Kai-Kai
Tang, Xu-Li
Liu, Yi-Sheng
Li, Ping-Lin
Li, Guo-Qiang
author_facet Gong, Kai-Kai
Tang, Xu-Li
Liu, Yi-Sheng
Li, Ping-Lin
Li, Guo-Qiang
author_sort Gong, Kai-Kai
collection PubMed
description Marine sponges continue to serve as a rich source of alkaloids possessing interesting biological activities and often exhibiting unique structural frameworks. In the current study, chemical investigation on the marine sponge Pericharax heteroraphis collected from the South China Sea yielded one new imidazole alkaloid named naamidine J (1) along with four known ones (2–5). Their structures were established by extensive spectroscopic methods and comparison of their data with those of the related known compounds. All the isolates possessed a central 2-aminoimidazole ring, substituted by one or two functionalized benzyl groups in some combination of the C4 and C5 positions. The cytotoxicities against selected HL-60, HeLa, A549 and K562 tumor cell lines and anti-H1N1 (Influenza a virus (IAV)) activity for the isolates were evaluated. Compounds 1 and 2 exhibited cytotoxicities against the K562 cell line with IC(50) values of 11.3 and 9.4 μM, respectively. Compound 5 exhibited weak anti-H1N1 (influenza a virus, IAV) activity with an inhibition ratio of 33%.
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spelling pubmed-62745322018-12-28 Imidazole Alkaloids from the South China Sea Sponge Pericharax heteroraphis and Their Cytotoxic and Antiviral Activities Gong, Kai-Kai Tang, Xu-Li Liu, Yi-Sheng Li, Ping-Lin Li, Guo-Qiang Molecules Communication Marine sponges continue to serve as a rich source of alkaloids possessing interesting biological activities and often exhibiting unique structural frameworks. In the current study, chemical investigation on the marine sponge Pericharax heteroraphis collected from the South China Sea yielded one new imidazole alkaloid named naamidine J (1) along with four known ones (2–5). Their structures were established by extensive spectroscopic methods and comparison of their data with those of the related known compounds. All the isolates possessed a central 2-aminoimidazole ring, substituted by one or two functionalized benzyl groups in some combination of the C4 and C5 positions. The cytotoxicities against selected HL-60, HeLa, A549 and K562 tumor cell lines and anti-H1N1 (Influenza a virus (IAV)) activity for the isolates were evaluated. Compounds 1 and 2 exhibited cytotoxicities against the K562 cell line with IC(50) values of 11.3 and 9.4 μM, respectively. Compound 5 exhibited weak anti-H1N1 (influenza a virus, IAV) activity with an inhibition ratio of 33%. MDPI 2016-01-26 /pmc/articles/PMC6274532/ /pubmed/26821008 http://dx.doi.org/10.3390/molecules21020150 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Gong, Kai-Kai
Tang, Xu-Li
Liu, Yi-Sheng
Li, Ping-Lin
Li, Guo-Qiang
Imidazole Alkaloids from the South China Sea Sponge Pericharax heteroraphis and Their Cytotoxic and Antiviral Activities
title Imidazole Alkaloids from the South China Sea Sponge Pericharax heteroraphis and Their Cytotoxic and Antiviral Activities
title_full Imidazole Alkaloids from the South China Sea Sponge Pericharax heteroraphis and Their Cytotoxic and Antiviral Activities
title_fullStr Imidazole Alkaloids from the South China Sea Sponge Pericharax heteroraphis and Their Cytotoxic and Antiviral Activities
title_full_unstemmed Imidazole Alkaloids from the South China Sea Sponge Pericharax heteroraphis and Their Cytotoxic and Antiviral Activities
title_short Imidazole Alkaloids from the South China Sea Sponge Pericharax heteroraphis and Their Cytotoxic and Antiviral Activities
title_sort imidazole alkaloids from the south china sea sponge pericharax heteroraphis and their cytotoxic and antiviral activities
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274532/
https://www.ncbi.nlm.nih.gov/pubmed/26821008
http://dx.doi.org/10.3390/molecules21020150
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