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Molecular Dynamics Simulations to Investigate the Binding Mode of the Natural Product Liphagal with Phosphoinositide 3-Kinase α

Phosphatidylinositol 3-kinase α (PI3Kα) is an attractive target for anticancer drug design. Liphagal, isolated from the marine sponge Aka coralliphaga, possesses the special “liphagane” meroterpenoid carbon skeleton and has been demonstrated as a PI3Kα inhibitor. Molecular docking and molecular dyna...

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Detalles Bibliográficos
Autores principales:	Gao, Yanjuan, Ma, Ying, Yang, Guangde, Li, Yiping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274547/ https://www.ncbi.nlm.nih.gov/pubmed/27367663 http://dx.doi.org/10.3390/molecules21070857

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