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Development of Mushroom-Based Cosmeceutical Formulations with Anti-Inflammatory, Anti-Tyrosinase, Antioxidant, and Antibacterial Properties

The cosmetic industry is in a constant search for natural compounds or extracts with relevant bioactive properties, which became valuable ingredients to design cosmeceutical formulations. Mushrooms have been markedly studied in terms of nutritional value and medicinal properties. However, there is s...

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Autores principales: Taofiq, Oludemi, Heleno, Sandrina A., Calhelha, Ricardo C., Alves, Maria José, Barros, Lillian, Barreiro, Maria Filomena, González-Paramás, Ana M., Ferreira, Isabel C. F. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274557/
https://www.ncbi.nlm.nih.gov/pubmed/27754433
http://dx.doi.org/10.3390/molecules21101372
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author Taofiq, Oludemi
Heleno, Sandrina A.
Calhelha, Ricardo C.
Alves, Maria José
Barros, Lillian
Barreiro, Maria Filomena
González-Paramás, Ana M.
Ferreira, Isabel C. F. R.
author_facet Taofiq, Oludemi
Heleno, Sandrina A.
Calhelha, Ricardo C.
Alves, Maria José
Barros, Lillian
Barreiro, Maria Filomena
González-Paramás, Ana M.
Ferreira, Isabel C. F. R.
author_sort Taofiq, Oludemi
collection PubMed
description The cosmetic industry is in a constant search for natural compounds or extracts with relevant bioactive properties, which became valuable ingredients to design cosmeceutical formulations. Mushrooms have been markedly studied in terms of nutritional value and medicinal properties. However, there is still slow progress in the biotechnological application of mushroom extracts in cosmetic formulations, either as antioxidants, anti-aging, antimicrobial, and anti-inflammatory agents or as hyperpigmentation correctors. In the present work, the cosmeceutical potential of ethanolic extracts prepared from Agaricus bisporus, Pleurotus ostreatus, and Lentinula edodes was analyzed in terms of anti-inflammatory, anti-tyrosinase, antioxidant, and antibacterial activities. The extracts were characterized in terms of phenolic acids and ergosterol composition, and further incorporated in a base cosmetic cream to achieve the same bioactive purposes. From the results obtained, the final cosmeceutical formulations presented 85%–100% of the phenolic acids and ergosterol levels found in the mushroom extracts, suggesting that there was no significant loss of bioactive compounds. The final cosmeceutical formulation also displayed all the ascribed bioactivities and as such, mushrooms can further be exploited as natural cosmeceutical ingredients.
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spelling pubmed-62745572018-12-28 Development of Mushroom-Based Cosmeceutical Formulations with Anti-Inflammatory, Anti-Tyrosinase, Antioxidant, and Antibacterial Properties Taofiq, Oludemi Heleno, Sandrina A. Calhelha, Ricardo C. Alves, Maria José Barros, Lillian Barreiro, Maria Filomena González-Paramás, Ana M. Ferreira, Isabel C. F. R. Molecules Article The cosmetic industry is in a constant search for natural compounds or extracts with relevant bioactive properties, which became valuable ingredients to design cosmeceutical formulations. Mushrooms have been markedly studied in terms of nutritional value and medicinal properties. However, there is still slow progress in the biotechnological application of mushroom extracts in cosmetic formulations, either as antioxidants, anti-aging, antimicrobial, and anti-inflammatory agents or as hyperpigmentation correctors. In the present work, the cosmeceutical potential of ethanolic extracts prepared from Agaricus bisporus, Pleurotus ostreatus, and Lentinula edodes was analyzed in terms of anti-inflammatory, anti-tyrosinase, antioxidant, and antibacterial activities. The extracts were characterized in terms of phenolic acids and ergosterol composition, and further incorporated in a base cosmetic cream to achieve the same bioactive purposes. From the results obtained, the final cosmeceutical formulations presented 85%–100% of the phenolic acids and ergosterol levels found in the mushroom extracts, suggesting that there was no significant loss of bioactive compounds. The final cosmeceutical formulation also displayed all the ascribed bioactivities and as such, mushrooms can further be exploited as natural cosmeceutical ingredients. MDPI 2016-10-14 /pmc/articles/PMC6274557/ /pubmed/27754433 http://dx.doi.org/10.3390/molecules21101372 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Taofiq, Oludemi
Heleno, Sandrina A.
Calhelha, Ricardo C.
Alves, Maria José
Barros, Lillian
Barreiro, Maria Filomena
González-Paramás, Ana M.
Ferreira, Isabel C. F. R.
Development of Mushroom-Based Cosmeceutical Formulations with Anti-Inflammatory, Anti-Tyrosinase, Antioxidant, and Antibacterial Properties
title Development of Mushroom-Based Cosmeceutical Formulations with Anti-Inflammatory, Anti-Tyrosinase, Antioxidant, and Antibacterial Properties
title_full Development of Mushroom-Based Cosmeceutical Formulations with Anti-Inflammatory, Anti-Tyrosinase, Antioxidant, and Antibacterial Properties
title_fullStr Development of Mushroom-Based Cosmeceutical Formulations with Anti-Inflammatory, Anti-Tyrosinase, Antioxidant, and Antibacterial Properties
title_full_unstemmed Development of Mushroom-Based Cosmeceutical Formulations with Anti-Inflammatory, Anti-Tyrosinase, Antioxidant, and Antibacterial Properties
title_short Development of Mushroom-Based Cosmeceutical Formulations with Anti-Inflammatory, Anti-Tyrosinase, Antioxidant, and Antibacterial Properties
title_sort development of mushroom-based cosmeceutical formulations with anti-inflammatory, anti-tyrosinase, antioxidant, and antibacterial properties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274557/
https://www.ncbi.nlm.nih.gov/pubmed/27754433
http://dx.doi.org/10.3390/molecules21101372
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