In Vitro Reversible and Time-Dependent CYP450 Inhibition Profiles of Medicinal Herbal Plant Extracts Newbouldia laevis and Cassia abbreviata: Implications for Herb-Drug Interactions

This study evaluated the effects of Newbouldia laevis and Cassia abbreviata extracts on CYP450 enzyme activity. Recombinant CYP450 enzyme and fluorogenic substrates were used for evaluating inhibition, allowing the assessment of herb–drug interactions (HDI). Phytochemical fingerprinting was performe...

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Detalles Bibliográficos
Autores principales: Thomford, Nicholas Ekow, Dzobo, Kevin, Chopera, Denis, Wonkam, Ambroise, Maroyi, Alfred, Blackhurst, Dee, Dandara, Collet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274561/
https://www.ncbi.nlm.nih.gov/pubmed/27399660
http://dx.doi.org/10.3390/molecules21070891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274561/
https://www.ncbi.nlm.nih.gov/pubmed/27399660
http://dx.doi.org/10.3390/molecules21070891

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