Design, Synthesis and Anticancer Evaluation of Novel Quinazoline-Sulfonamide Hybrids

By combining the structural features of quinazoline and sulfonamides, novel hybrid compounds 2–21 were synthesized using a simple and convenient method. Evaluation of these compounds against different cell lines identified compounds 7 and 17 as most active anticancer agents as they showed effectiven...

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Autores principales: Ghorab, Mostafa M., Alsaid, Mansour S., Al-Dosari, Mohammed S., El-Gazzar, Marwa G., Parvez, Mohammad K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274562/
https://www.ncbi.nlm.nih.gov/pubmed/26861266
http://dx.doi.org/10.3390/molecules21020189
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author Ghorab, Mostafa M.
Alsaid, Mansour S.
Al-Dosari, Mohammed S.
El-Gazzar, Marwa G.
Parvez, Mohammad K.
author_facet Ghorab, Mostafa M.
Alsaid, Mansour S.
Al-Dosari, Mohammed S.
El-Gazzar, Marwa G.
Parvez, Mohammad K.
author_sort Ghorab, Mostafa M.
collection PubMed
description By combining the structural features of quinazoline and sulfonamides, novel hybrid compounds 2–21 were synthesized using a simple and convenient method. Evaluation of these compounds against different cell lines identified compounds 7 and 17 as most active anticancer agents as they showed effectiveness on the four tested cell lines. The anticancer screening results of the tested compounds provides an encouraging framework that could lead to the development of potent new anticancer agents.
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spelling pubmed-62745622018-12-28 Design, Synthesis and Anticancer Evaluation of Novel Quinazoline-Sulfonamide Hybrids Ghorab, Mostafa M. Alsaid, Mansour S. Al-Dosari, Mohammed S. El-Gazzar, Marwa G. Parvez, Mohammad K. Molecules Article By combining the structural features of quinazoline and sulfonamides, novel hybrid compounds 2–21 were synthesized using a simple and convenient method. Evaluation of these compounds against different cell lines identified compounds 7 and 17 as most active anticancer agents as they showed effectiveness on the four tested cell lines. The anticancer screening results of the tested compounds provides an encouraging framework that could lead to the development of potent new anticancer agents. MDPI 2016-02-04 /pmc/articles/PMC6274562/ /pubmed/26861266 http://dx.doi.org/10.3390/molecules21020189 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ghorab, Mostafa M.
Alsaid, Mansour S.
Al-Dosari, Mohammed S.
El-Gazzar, Marwa G.
Parvez, Mohammad K.
Design, Synthesis and Anticancer Evaluation of Novel Quinazoline-Sulfonamide Hybrids
title Design, Synthesis and Anticancer Evaluation of Novel Quinazoline-Sulfonamide Hybrids
title_full Design, Synthesis and Anticancer Evaluation of Novel Quinazoline-Sulfonamide Hybrids
title_fullStr Design, Synthesis and Anticancer Evaluation of Novel Quinazoline-Sulfonamide Hybrids
title_full_unstemmed Design, Synthesis and Anticancer Evaluation of Novel Quinazoline-Sulfonamide Hybrids
title_short Design, Synthesis and Anticancer Evaluation of Novel Quinazoline-Sulfonamide Hybrids
title_sort design, synthesis and anticancer evaluation of novel quinazoline-sulfonamide hybrids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274562/
https://www.ncbi.nlm.nih.gov/pubmed/26861266
http://dx.doi.org/10.3390/molecules21020189
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