Cargando…

Design, Synthesis and Anticancer Evaluation of Novel Quinazoline-Sulfonamide Hybrids

By combining the structural features of quinazoline and sulfonamides, novel hybrid compounds 2–21 were synthesized using a simple and convenient method. Evaluation of these compounds against different cell lines identified compounds 7 and 17 as most active anticancer agents as they showed effectiven...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ghorab, Mostafa M., Alsaid, Mansour S., Al-Dosari, Mohammed S., El-Gazzar, Marwa G., Parvez, Mohammad K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274562/ https://www.ncbi.nlm.nih.gov/pubmed/26861266 http://dx.doi.org/10.3390/molecules21020189

Ejemplares similares

In-Vitro Anticancer Evaluation of Some Novel Thioureido-Benzensulfonamide Derivatives
por: Ghorab, Mostafa M., et al.
Publicado: (2016)

Synthesis and Anti-Breast Cancer Evaluation of Novel N-(Guanidinyl)benzenesulfonamides
por: Ghorab, Mostafa M., et al.
Publicado: (2014)

Synthesis, Characterization and Anti-Breast Cancer Activity of New 4-Aminoantipyrine-Based Heterocycles
por: Ghorab, Mostafa M., et al.
Publicado: (2014)

Antimicrobial and anticancer activity of some novel fluorinated thiourea derivatives carrying sulfonamide moieties: synthesis, biological evaluation and molecular docking
por: Ghorab, Mostafa M., et al.
Publicado: (2017)

VEGFR-2 inhibitors and apoptosis inducers: synthesis and molecular design of new benzo[g]quinazolin bearing benzenesulfonamide moiety
por: Ghorab, Mostafa M., et al.
Publicado: (2017)

Design, synthesis and anticancer activity of some novel thioureido-benzenesulfonamides incorporated biologically active moieties
por: Ghorab, Mostafa M., et al.
Publicado: (2016)

Novel chloroquinoline derivatives incorporating biologically active benzenesulfonamide moiety: synthesis, cytotoxic activity and molecular docking
por: Ghorab, Mostafa M., et al.
Publicado: (2016)

Benzo[g]quinazolin-based scaffold derivatives as dual EGFR/HER2 inhibitors
por: Ghorab, Mostafa M., et al.
Publicado: (2017)

The Antiproliferative and Apoptotic Effects of a Novel Quinazoline Carrying Substituted-Sulfonamides: In Vitro and Molecular Docking Study
por: Alqahtani, Ali S., et al.
Publicado: (2022)

Cytotoxicity of Newly Synthesized Quinazoline–Sulfonamide Derivatives in Human Leukemia Cell Lines and Their Effect on Hematopoiesis in Zebrafish Embryos
por: Alqahtani, Ali S., et al.
Publicado: (2022)

Synthesis and anticancer activity of new quinazoline derivatives
por: Abuelizz, Hatem A., et al.
Publicado: (2017)

Novel Sulfonamide–Triazine Hybrid Derivatives: Docking, Synthesis, and Biological Evaluation as Anticancer Agents
por: Alelaimat, Mahmoud A., et al.
Publicado: (2023)

New terpenic and phenolic compounds from Suaeda monoica reverse oxidative and apoptotic damages in human endothelial cells
por: Parvez, Mohammad K., et al.
Publicado: (2021)

Hepatoprotective effect of Solanum surattense leaf extract against chemical- induced oxidative and apoptotic injury in rats
por: Parvez, Mohammad K., et al.
Publicado: (2019)

Synthesis, docking study and biological evaluation of some new thiourea derivatives bearing benzenesulfonamide moiety
por: Ghorab, Mostafa M., et al.
Publicado: (2017)

Synthesis and Anticancer Activity Assay of Novel Chalcone-Sulfonamide Derivatives
por: Pesaran Seiied Bonakdar, Ahmad, et al.
Publicado: (2017)

Synthesis of chalcone incorporated quinazoline derivatives as anticancer agents
por: Madhavi, Sapavat, et al.
Publicado: (2017)

Novel iodoquinazolinones bearing sulfonamide moiety as potential antioxidants and neuroprotectors
por: Soliman, Aiten M., et al.
Publicado: (2023)

Dapson in heterocyclic chemistry, part VIII: synthesis, molecular docking and anticancer activity of some novel sulfonylbiscompounds carrying biologically active 1,3-dihydropyridine, chromene and chromenopyridine moieties
por: Al-Said, Mansour S, et al.
Publicado: (2012)

Treatment with Rhus tripartita extract curtails isoproterenol-elicited cardiotoxicity and oxidative stress in rats
por: Shahat, Abdelaaty A., et al.
Publicado: (2016)

Design, synthesis, anticancer activity and docking studies of novel quinazoline-based thiazole derivatives as EGFR kinase inhibitors
por: Raghu, M.S., et al.
Publicado: (2023)

Design, Synthesis, and Antitumor Activity of Novel Quinazoline Derivatives
por: Wang, Liuchang, et al.
Publicado: (2017)

Absolute configuration of (1S,2S)-3-methyl-2-phenyl-2,3-dihydrothiazolo[2,3-b]quinazolin-5-one
por: Ghorab, Mostafa. M., et al.
Publicado: (2012)

4-[(5,5-Dimethyl-3-oxocyclohex-1-enyl)amino]benzenesulfonamide
por: Al-Said, Mansour S., et al.
Publicado: (2012)

Design, synthesis, and molecular docking studies of N-substituted sulfonamides as potential anticancer therapeutics
por: Babalola, Ibrahim T., et al.
Publicado: (2023)

Hepatoprotective and Antiviral Efficacy of Acacia mellifera Leaves Fractions against Hepatitis B Virus
por: Arbab, Ahmed H., et al.
Publicado: (2015)

Terminators or Guardians? Design, Synthesis, and Cytotoxicity Profiling of Chalcone-Sulfonamide Hybrids
por: Aboukhatwa, Shaimaa M., et al.
Publicado: (2023)

Novel quinazoline-1,2,3-triazole hybrids with anticancer and MET kinase targeting properties
por: Mortazavi, Motahareh, et al.
Publicado: (2023)

Therapeutic efficacy of ethanolic extract of Aerva javanica aerial parts in the amelioration of CCl(4)-induced hepatotoxicity and oxidative damage in rats
por: Arbab, Ahmed H., et al.
Publicado: (2016)

Protective effect of Atriplex suberecta extract against oxidative and apoptotic hepatotoxicity
por: Parvez, Mohammad K., et al.
Publicado: (2018)

Synthesis, biological evaluation, and computational studies of some novel quinazoline derivatives as anticancer agents
por: Emami, Leila, et al.
Publicado: (2022)

Synthesis, Antimicrobial, and Antibiofilm Activities of Some Novel 7-Methoxyquinoline Derivatives Bearing Sulfonamide Moiety against Urinary Tract Infection-Causing Pathogenic Microbes
por: Ghorab, Mostafa M., et al.
Publicado: (2023)

(E)-4-Amino-N-(1,2-dihydropyridin-2-ylidene)benzenesulfonamide nitromethane monosolvate
por: Ghorab, Mostafa M., et al.
Publicado: (2012)

Synthesis of Triazole-Substituted Quinazoline Hybrids for Anticancer Activity and a Lead Compound as the EGFR Blocker and ROS Inducer Agent
por: Banerji, Biswadip, et al.
Publicado: (2018)

Proanthocyanidins from the stem bark of Rhus tripartita ameliorate methylgloxal-induced endothelial cell apoptosis
por: Alqahtani, Ali S., et al.
Publicado: (2019)

Novel plant inducers of PXR-dependent cytochrome P450 3A4 expression in HepG2 cells
por: Al-Dosari, Mohammed S., et al.
Publicado: (2018)

An Update on Synthesis of Coumarin Sulfonamides as Enzyme Inhibitors and Anticancer Agents
por: Rubab, Laila, et al.
Publicado: (2022)

4-{[7-(Trifluoromethyl)quinolin-4-yl]amino}benzenesulfonamide–ethanol–methanol (1/0.47/0.53)
por: Ghorab, Mostafa M., et al.
Publicado: (2012)

Pyrazole-sulfonamide scaffold featuring dual-tail strategy as apoptosis inducers in colon cancer
por: El-Hazek, Reham M. M., et al.
Publicado: (2023)

Novel quinazoline-based sulfonamide derivative (3D) induces apoptosis in colorectal cancer by inhibiting JAK2–STAT3 pathway
por: Al-Obeed, Omar, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_relqgurea8ibj10jhl1kclo8dh