Genome-wide meta-analysis of SNP-by-ACEI/ARB and SNP-by-thiazide diuretic and effect on serum potassium in cohorts of European and African ancestry

We evaluated interactions of SNP-by-ACE-I/ARB and SNP-by-TD on serum potassium (K+) among users of antihypertensive treatments (anti-HTN). Our study included 7 European-ancestry (EA) (N=4835) and 4 African-ancestry (AA) cohorts (N=2016). We performed race-stratified, fixed-effect, inverse-variance-w...

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Detalles Bibliográficos
Autores principales: Irvin, Marguerite R, Sitlani, Colleen M, Noordam, Raymond, Avery, Christie L, Bis, Joshua C, Floyd, James S, Li, Jin, Limdi, Nita A, Srinivasasainagendra, Vinodh, Stewart, James, de Mutsert, Renée, Mook-Kanamori, Dennis O, Lipovich, Leonard, Kleinbrink, Erica L, Smith, Albert, Bartz, Traci M, Whitsel, Eric A, Uitterlinden, Andre G, Wiggins, Kerri L, Wilson, James G, Zhi, Degui, Stricker, Bruno H, Rotter, Jerome I, Arnett, Donna K, Psaty, Bruce M, Lange, Leslie A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274589/
https://www.ncbi.nlm.nih.gov/pubmed/29855607
http://dx.doi.org/10.1038/s41397-018-0021-9

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