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Insulin Receptor Isoforms in Cancer

The insulin receptor (IR) mediates both metabolic and mitogenic effects especially when overexpressed or in clinical conditions with compensatory hyperinsulinemia, due to the metabolic pathway resistance, as obesity diabetes. In many cancers, IR is overexpressed preferentially as IR-A isoform, deriv...

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Detalles Bibliográficos
Autores principales:	Vella, Veronica, Milluzzo, Agostino, Scalisi, Nunzio Massimo, Vigneri, Paolo, Sciacca, Laura
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274710/ https://www.ncbi.nlm.nih.gov/pubmed/30453495 http://dx.doi.org/10.3390/ijms19113615

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