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The Question of a Role for Statins in Age-Related Macular Degeneration

Age-related macular degeneration (AMD) is the leading cause of irreversible central vision loss in patients over the age of 65 years in industrialized countries. Epidemiologic studies suggest that high dietary fat intake is a risk factor for the development and progression of both vascular and retin...

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Detalles Bibliográficos
Autores principales: Roizenblatt, Marina, Naranjit, Nara, Maia, Mauricio, Gehlbach, Peter L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274767/
https://www.ncbi.nlm.nih.gov/pubmed/30469381
http://dx.doi.org/10.3390/ijms19113688
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author Roizenblatt, Marina
Naranjit, Nara
Maia, Mauricio
Gehlbach, Peter L.
author_facet Roizenblatt, Marina
Naranjit, Nara
Maia, Mauricio
Gehlbach, Peter L.
author_sort Roizenblatt, Marina
collection PubMed
description Age-related macular degeneration (AMD) is the leading cause of irreversible central vision loss in patients over the age of 65 years in industrialized countries. Epidemiologic studies suggest that high dietary fat intake is a risk factor for the development and progression of both vascular and retinal disease. These, and other associations, suggest a hypothesis linking elevated cholesterol and AMD progression. It follows, therefore, that cholesterol-lowering medications, such as statins, may influence the onset and progression of AMD. However, the findings have been inconclusive as to whether statins play a role in AMD. Due to the significant public health implications of a potential inhibitory effect of statins on the onset and progression of AMD, it is important to continually evaluate emerging findings germane to this question.
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spelling pubmed-62747672018-12-15 The Question of a Role for Statins in Age-Related Macular Degeneration Roizenblatt, Marina Naranjit, Nara Maia, Mauricio Gehlbach, Peter L. Int J Mol Sci Review Age-related macular degeneration (AMD) is the leading cause of irreversible central vision loss in patients over the age of 65 years in industrialized countries. Epidemiologic studies suggest that high dietary fat intake is a risk factor for the development and progression of both vascular and retinal disease. These, and other associations, suggest a hypothesis linking elevated cholesterol and AMD progression. It follows, therefore, that cholesterol-lowering medications, such as statins, may influence the onset and progression of AMD. However, the findings have been inconclusive as to whether statins play a role in AMD. Due to the significant public health implications of a potential inhibitory effect of statins on the onset and progression of AMD, it is important to continually evaluate emerging findings germane to this question. MDPI 2018-11-21 /pmc/articles/PMC6274767/ /pubmed/30469381 http://dx.doi.org/10.3390/ijms19113688 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Roizenblatt, Marina
Naranjit, Nara
Maia, Mauricio
Gehlbach, Peter L.
The Question of a Role for Statins in Age-Related Macular Degeneration
title The Question of a Role for Statins in Age-Related Macular Degeneration
title_full The Question of a Role for Statins in Age-Related Macular Degeneration
title_fullStr The Question of a Role for Statins in Age-Related Macular Degeneration
title_full_unstemmed The Question of a Role for Statins in Age-Related Macular Degeneration
title_short The Question of a Role for Statins in Age-Related Macular Degeneration
title_sort question of a role for statins in age-related macular degeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274767/
https://www.ncbi.nlm.nih.gov/pubmed/30469381
http://dx.doi.org/10.3390/ijms19113688
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