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The Question of a Role for Statins in Age-Related Macular Degeneration
Age-related macular degeneration (AMD) is the leading cause of irreversible central vision loss in patients over the age of 65 years in industrialized countries. Epidemiologic studies suggest that high dietary fat intake is a risk factor for the development and progression of both vascular and retin...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274767/ https://www.ncbi.nlm.nih.gov/pubmed/30469381 http://dx.doi.org/10.3390/ijms19113688 |
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author | Roizenblatt, Marina Naranjit, Nara Maia, Mauricio Gehlbach, Peter L. |
author_facet | Roizenblatt, Marina Naranjit, Nara Maia, Mauricio Gehlbach, Peter L. |
author_sort | Roizenblatt, Marina |
collection | PubMed |
description | Age-related macular degeneration (AMD) is the leading cause of irreversible central vision loss in patients over the age of 65 years in industrialized countries. Epidemiologic studies suggest that high dietary fat intake is a risk factor for the development and progression of both vascular and retinal disease. These, and other associations, suggest a hypothesis linking elevated cholesterol and AMD progression. It follows, therefore, that cholesterol-lowering medications, such as statins, may influence the onset and progression of AMD. However, the findings have been inconclusive as to whether statins play a role in AMD. Due to the significant public health implications of a potential inhibitory effect of statins on the onset and progression of AMD, it is important to continually evaluate emerging findings germane to this question. |
format | Online Article Text |
id | pubmed-6274767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62747672018-12-15 The Question of a Role for Statins in Age-Related Macular Degeneration Roizenblatt, Marina Naranjit, Nara Maia, Mauricio Gehlbach, Peter L. Int J Mol Sci Review Age-related macular degeneration (AMD) is the leading cause of irreversible central vision loss in patients over the age of 65 years in industrialized countries. Epidemiologic studies suggest that high dietary fat intake is a risk factor for the development and progression of both vascular and retinal disease. These, and other associations, suggest a hypothesis linking elevated cholesterol and AMD progression. It follows, therefore, that cholesterol-lowering medications, such as statins, may influence the onset and progression of AMD. However, the findings have been inconclusive as to whether statins play a role in AMD. Due to the significant public health implications of a potential inhibitory effect of statins on the onset and progression of AMD, it is important to continually evaluate emerging findings germane to this question. MDPI 2018-11-21 /pmc/articles/PMC6274767/ /pubmed/30469381 http://dx.doi.org/10.3390/ijms19113688 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Roizenblatt, Marina Naranjit, Nara Maia, Mauricio Gehlbach, Peter L. The Question of a Role for Statins in Age-Related Macular Degeneration |
title | The Question of a Role for Statins in Age-Related Macular Degeneration |
title_full | The Question of a Role for Statins in Age-Related Macular Degeneration |
title_fullStr | The Question of a Role for Statins in Age-Related Macular Degeneration |
title_full_unstemmed | The Question of a Role for Statins in Age-Related Macular Degeneration |
title_short | The Question of a Role for Statins in Age-Related Macular Degeneration |
title_sort | question of a role for statins in age-related macular degeneration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274767/ https://www.ncbi.nlm.nih.gov/pubmed/30469381 http://dx.doi.org/10.3390/ijms19113688 |
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