Cargando…

Large-Scale Simulation of the Phenotypical Variability Induced by Loss-of-Function Long QT Mutations in Human Induced Pluripotent Stem Cell Cardiomyocytes

Loss-of-function long QT (LQT) mutations inducing LQT1 and LQT2 syndromes have been successfully translated to human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) used as disease-specific models. However, their in vitro investigation mainly relies on experiments using small number...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paci, Michelangelo, Casini, Simona, Bellin, Milena, Hyttinen, Jari, Severi, Stefano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274824/ https://www.ncbi.nlm.nih.gov/pubmed/30428582 http://dx.doi.org/10.3390/ijms19113583

Ejemplares similares

Phenotypic variability in LQT3 human induced pluripotent stem cell-derived cardiomyocytes and their response to antiarrhythmic pharmacologic therapy: An in silico approach
por: Paci, Michelangelo, et al.
Publicado: (2017)

Human induced pluripotent stem cell‐derived versus adult cardiomyocytes: an in silico electrophysiological study on effects of ionic current block
por: Paci, M, et al.
Publicado: (2015)

Automatic Optimization of an in Silico Model of Human iPSC Derived Cardiomyocytes Recapitulating Calcium Handling Abnormalities
por: Paci, Michelangelo, et al.
Publicado: (2018)

Simulation of the Effects of Extracellular Calcium Changes Leads to a Novel Computational Model of Human Ventricular Action Potential With a Revised Calcium Handling
por: Bartolucci, Chiara, et al.
Publicado: (2020)

A mathematical model of hiPSC cardiomyocytes electromechanics
por: Forouzandehmehr, Mohamadamin, et al.
Publicado: (2021)

A new hERG allosteric modulator rescues genetic and drug‐induced long‐QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells
por: Sala, Luca, et al.
Publicado: (2016)

All-Optical Electrophysiology Refines Populations of In Silico Human iPSC-CMs for Drug Evaluation
por: Paci, Michelangelo, et al.
Publicado: (2020)

A Novel In Silico Electromechanical Model of Human Ventricular Cardiomyocyte
por: Bartolucci, Chiara, et al.
Publicado: (2022)

Cardiomyocyte MEA Data Analysis (CardioMDA) – A Novel Field Potential Data Analysis Software for Pluripotent Stem Cell Derived Cardiomyocytes
por: Pradhapan, Paruthi, et al.
Publicado: (2013)

Distinct electrophysiological and mechanical beating phenotypes of long QT syndrome type 1-specific cardiomyocytes carrying different mutations
por: Kiviaho, Anna L., et al.
Publicado: (2015)

Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes
por: Matsa, Elena, et al.
Publicado: (2014)

Modeling Short QT Syndrome Using Human‐Induced Pluripotent Stem Cell–Derived Cardiomyocytes
por: El‐Battrawy, Ibrahim, et al.
Publicado: (2018)

Long QT Syndrome Modelling with Cardiomyocytes Derived from Human-induced Pluripotent Stem Cells
por: Sala, Luca, et al.
Publicado: (2019)

“Thorough QT/QTc in a Dish”: Can Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Predict Thorough QT Outcomes?
por: Vargas, Hugo M.
Publicado: (2019)

The Disease-Specific Phenotype in Cardiomyocytes Derived from Induced Pluripotent Stem Cells of Two Long QT Syndrome Type 3 Patients
por: Fatima, Azra, et al.
Publicado: (2013)

Video image-based analysis of single human induced pluripotent stem cell derived cardiomyocyte beating dynamics using digital image correlation
por: Ahola, Antti, et al.
Publicado: (2014)

Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome
por: Bellin, Milena, et al.
Publicado: (2013)

Effects of cardioactive drugs on human induced pluripotent stem cell derived long QT syndrome cardiomyocytes
por: Kuusela, Jukka, et al.
Publicado: (2016)

Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come?
por: Sala, Luca, et al.
Publicado: (2016)

Altered contractility in mutation-specific hypertrophic cardiomyopathy: A mechano-energetic in silico study with pharmacological insights
por: Forouzandehmehr, Mohamadamin, et al.
Publicado: (2022)

Mathematical modelling of the action potential of human embryonic stem cell derived cardiomyocytes
por: Paci, Michelangelo, et al.
Publicado: (2012)

Deciphering Common Long QT Syndrome Using CRISPR/Cas9 in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
por: Song, Yongfei, et al.
Publicado: (2022)

Human heart disease: lessons from human pluripotent stem cell-derived cardiomyocytes
por: Giacomelli, E., et al.
Publicado: (2017)

Switch From Fetal to Adult SCN5A Isoform in Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Unmasks the Cellular Phenotype of a Conduction Disease–Causing Mutation
por: Veerman, Christiaan C., et al.
Publicado: (2017)

Induced Pluripotent Stem Cell-Derived Cardiomyocytes with SCN5A R1623Q Mutation Associated with Severe Long QT Syndrome in Fetuses and Neonates Recapitulates Pathophysiological Phenotypes
por: Hayama, Emiko, et al.
Publicado: (2021)

Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation
por: Matsa, Elena, et al.
Publicado: (2011)

Antiarrhythmic Effects of Vernakalant in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes from a Patient with Short QT Syndrome Type 1
por: Xu, Qiang, et al.
Publicado: (2022)

Electrophysiological Analysis of human Pluripotent Stem Cell-derived Cardiomyocytes (hPSC-CMs) Using Multi-electrode Arrays (MEAs)
por: Sala, Luca, et al.
Publicado: (2017)

Cardiomyopathy phenotypes in human-induced pluripotent stem cell-derived cardiomyocytes—a systematic review
por: Eschenhagen, Thomas, et al.
Publicado: (2018)

Phenotype-Based High-Throughput Classification of Long QT Syndrome Subtypes Using Human Induced Pluripotent Stem Cells
por: Yoshinaga, Daisuke, et al.
Publicado: (2019)

Fatty Acid-Treated Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes Exhibit Adult Cardiomyocyte-Like Energy Metabolism Phenotypes
por: Horikoshi, Yuichi, et al.
Publicado: (2019)

Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells
por: Giacomelli, Elisa, et al.
Publicado: (2017)

Co-culture of induced pluripotent stem cells with cardiomyocytes is sufficient to promote their differentiation into cardiomyocytes
por: Chu, Axel J., et al.
Publicado: (2020)

Multiplexing physical stimulation on single human induced pluripotent stem cell-derived cardiomyocytes for phenotype modulation
por: Kit-Anan, Worrapong, et al.
Publicado: (2021)

Multifocal optical projection microscopy enables label-free 3D measurement of cardiomyocyte cluster contractility
por: Belay, Birhanu, et al.
Publicado: (2023)

Endothelin‐1 Induces Myofibrillar Disarray and Contractile Vector Variability in Hypertrophic Cardiomyopathy–Induced Pluripotent Stem Cell–Derived Cardiomyocytes
por: Tanaka, Atsushi, et al.
Publicado: (2014)

A computational model of induced pluripotent stem‐cell derived cardiomyocytes incorporating experimental variability from multiple data sources
por: Kernik, Divya C., et al.
Publicado: (2019)

QT Adaptation and Intrinsic QT Variability in Congenital Long QT Syndrome
por: Seethala, Srikanth, et al.
Publicado: (2015)

Computational Model of Ca(2+) Wave Propagation in Human Retinal Pigment Epithelial ARPE-19 Cells
por: Vainio, Iina, et al.
Publicado: (2015)

Texture Descriptors Ensembles Enable Image-Based Classification of Maturation of Human Stem Cell-Derived Retinal Pigmented Epithelium
por: Nanni, Loris, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_gagve0iloh5f00tpcan7udojua