Prevention Is the Best Treatment: The Case for Understanding the Transition from Monoclonal Gammopathy of Undetermined Significance to Myeloma

Multiple myeloma is an invariably fatal cancer of plasma cells. Despite tremendous advances in treatment, this malignancy remains incurable in most individuals. We postulate that strategies aimed at prevention have the potential to be more effective in preventing myeloma-related death than additiona...

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Detalles Bibliográficos
Autores principales: Tomasson, Michael H., Ali, Mahmoud, De Oliveira, Vanessa, Xiao, Qian, Jethava, Yogesh, Zhan, Fenghuang, Fitzsimmons, Adam M., Bates, Melissa L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274834/
https://www.ncbi.nlm.nih.gov/pubmed/30453544
http://dx.doi.org/10.3390/ijms19113621
Descripción
Sumario:Multiple myeloma is an invariably fatal cancer of plasma cells. Despite tremendous advances in treatment, this malignancy remains incurable in most individuals. We postulate that strategies aimed at prevention have the potential to be more effective in preventing myeloma-related death than additional pharmaceutical strategies aimed at treating advanced disease. Here, we present a rationale for the development of prevention therapy and highlight potential target areas of study.

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