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Effects of an Interchain Disulfide Bond on Tropomyosin Structure: A Molecular Dynamics Study

Tropomyosin (Tpm) is a coiled-coil actin-binding dimer protein that participates in the regulation of muscle contraction. Both Tpm chains contain Cys190 residues which are normally in the reduced state, but form an interchain disulfide bond in failing heart. Changes in structural and functional prop...

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Detalles Bibliográficos
Autores principales:	Koubassova, Natalia A., Bershitsky, Sergey Y., Tsaturyan, Andrey K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274839/ https://www.ncbi.nlm.nih.gov/pubmed/30373319 http://dx.doi.org/10.3390/ijms19113376

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