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Metabolomic Signature in Sera of Multiple Sclerosis Patients during Pregnancy

Multiple sclerosis (MuS) is an autoimmune disease of the central nervous system characterized by neuroinflammation, neurodegeneration, and degradation of the myelin sheath. Epidemiological studies have shown that the female gender is more susceptible than the male gender to MuS development, with a f...

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Autores principales: Rossi, Claudia, Cicalini, Ilaria, Zucchelli, Mirco, di Ioia, Maria, Onofrj, Marco, Federici, Luca, Del Boccio, Piero, Pieragostino, Damiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274842/
https://www.ncbi.nlm.nih.gov/pubmed/30441762
http://dx.doi.org/10.3390/ijms19113589
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author Rossi, Claudia
Cicalini, Ilaria
Zucchelli, Mirco
di Ioia, Maria
Onofrj, Marco
Federici, Luca
Del Boccio, Piero
Pieragostino, Damiana
author_facet Rossi, Claudia
Cicalini, Ilaria
Zucchelli, Mirco
di Ioia, Maria
Onofrj, Marco
Federici, Luca
Del Boccio, Piero
Pieragostino, Damiana
author_sort Rossi, Claudia
collection PubMed
description Multiple sclerosis (MuS) is an autoimmune disease of the central nervous system characterized by neuroinflammation, neurodegeneration, and degradation of the myelin sheath. Epidemiological studies have shown that the female gender is more susceptible than the male gender to MuS development, with a female-to-male ratio of 2:1. Despite this high onset, women have a better prognosis than men, and the frequency of the relapsing phase decreases during pregnancy, while it increases soon after birth. Therefore, it is interesting to investigate hormonal fluctuations during pregnancy and whether they correlate with metabolic signatures. To gain a deeper inside into the biochemical mechanism of such a multifactorial disease, we adopted targeted metabolomics approaches for the determination of many serum metabolites in 12 pregnant women affected by MuS by mass spectrometry analysis. Our data show a characteristic hormonal fluctuation for estrogens and progesterone, as expected. They also highlight other interesting hormonal alterations for cortisol, corticosterone, 11-deoxycortisol, 4-androstene-3,17-dione, testosterone, and 17α-hydroxyprogesterone. Furthermore, a negative correlation with progesterone levels was observed for amino acids and for acylcarnitines, while an imbalance of different sphingolipids pathways was found during pregnancy. In conclusion, these data are in agreement with the characteristic clinical signs of MuS patients during pregnancy and, if confirmed, they may add an important tessera in the complex mosaic of maternal neuroprotection.
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spelling pubmed-62748422018-12-15 Metabolomic Signature in Sera of Multiple Sclerosis Patients during Pregnancy Rossi, Claudia Cicalini, Ilaria Zucchelli, Mirco di Ioia, Maria Onofrj, Marco Federici, Luca Del Boccio, Piero Pieragostino, Damiana Int J Mol Sci Article Multiple sclerosis (MuS) is an autoimmune disease of the central nervous system characterized by neuroinflammation, neurodegeneration, and degradation of the myelin sheath. Epidemiological studies have shown that the female gender is more susceptible than the male gender to MuS development, with a female-to-male ratio of 2:1. Despite this high onset, women have a better prognosis than men, and the frequency of the relapsing phase decreases during pregnancy, while it increases soon after birth. Therefore, it is interesting to investigate hormonal fluctuations during pregnancy and whether they correlate with metabolic signatures. To gain a deeper inside into the biochemical mechanism of such a multifactorial disease, we adopted targeted metabolomics approaches for the determination of many serum metabolites in 12 pregnant women affected by MuS by mass spectrometry analysis. Our data show a characteristic hormonal fluctuation for estrogens and progesterone, as expected. They also highlight other interesting hormonal alterations for cortisol, corticosterone, 11-deoxycortisol, 4-androstene-3,17-dione, testosterone, and 17α-hydroxyprogesterone. Furthermore, a negative correlation with progesterone levels was observed for amino acids and for acylcarnitines, while an imbalance of different sphingolipids pathways was found during pregnancy. In conclusion, these data are in agreement with the characteristic clinical signs of MuS patients during pregnancy and, if confirmed, they may add an important tessera in the complex mosaic of maternal neuroprotection. MDPI 2018-11-14 /pmc/articles/PMC6274842/ /pubmed/30441762 http://dx.doi.org/10.3390/ijms19113589 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rossi, Claudia
Cicalini, Ilaria
Zucchelli, Mirco
di Ioia, Maria
Onofrj, Marco
Federici, Luca
Del Boccio, Piero
Pieragostino, Damiana
Metabolomic Signature in Sera of Multiple Sclerosis Patients during Pregnancy
title Metabolomic Signature in Sera of Multiple Sclerosis Patients during Pregnancy
title_full Metabolomic Signature in Sera of Multiple Sclerosis Patients during Pregnancy
title_fullStr Metabolomic Signature in Sera of Multiple Sclerosis Patients during Pregnancy
title_full_unstemmed Metabolomic Signature in Sera of Multiple Sclerosis Patients during Pregnancy
title_short Metabolomic Signature in Sera of Multiple Sclerosis Patients during Pregnancy
title_sort metabolomic signature in sera of multiple sclerosis patients during pregnancy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274842/
https://www.ncbi.nlm.nih.gov/pubmed/30441762
http://dx.doi.org/10.3390/ijms19113589
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