Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases

Lipid and immune pathways are crucial in the pathophysiology of metabolic and cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to immunity and inflammation, thus holding a key role in the emergence and progression of frequent diseases such as obesity, diabet...

Descripción completa

Detalles Bibliográficos
Autores principales: Sonnweber, Thomas, Pizzini, Alex, Nairz, Manfred, Weiss, Günter, Tancevski, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274989/
https://www.ncbi.nlm.nih.gov/pubmed/30360467
http://dx.doi.org/10.3390/ijms19113285
_version_ 1783377735935066112
author Sonnweber, Thomas
Pizzini, Alex
Nairz, Manfred
Weiss, Günter
Tancevski, Ivan
author_facet Sonnweber, Thomas
Pizzini, Alex
Nairz, Manfred
Weiss, Günter
Tancevski, Ivan
author_sort Sonnweber, Thomas
collection PubMed
description Lipid and immune pathways are crucial in the pathophysiology of metabolic and cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to immunity and inflammation, thus holding a key role in the emergence and progression of frequent diseases such as obesity, diabetes, non-alcoholic fatty liver disease, and cardiovascular disease. We herein present a synopsis of AA metabolism in human health, tissue homeostasis, and immunity, and explore the role of the AA metabolome in diverse pathophysiological conditions and diseases.
format Online
Article
Text
id pubmed-6274989
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62749892018-12-15 Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases Sonnweber, Thomas Pizzini, Alex Nairz, Manfred Weiss, Günter Tancevski, Ivan Int J Mol Sci Review Lipid and immune pathways are crucial in the pathophysiology of metabolic and cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to immunity and inflammation, thus holding a key role in the emergence and progression of frequent diseases such as obesity, diabetes, non-alcoholic fatty liver disease, and cardiovascular disease. We herein present a synopsis of AA metabolism in human health, tissue homeostasis, and immunity, and explore the role of the AA metabolome in diverse pathophysiological conditions and diseases. MDPI 2018-10-23 /pmc/articles/PMC6274989/ /pubmed/30360467 http://dx.doi.org/10.3390/ijms19113285 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sonnweber, Thomas
Pizzini, Alex
Nairz, Manfred
Weiss, Günter
Tancevski, Ivan
Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases
title Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases
title_full Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases
title_fullStr Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases
title_full_unstemmed Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases
title_short Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases
title_sort arachidonic acid metabolites in cardiovascular and metabolic diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274989/
https://www.ncbi.nlm.nih.gov/pubmed/30360467
http://dx.doi.org/10.3390/ijms19113285
work_keys_str_mv AT sonnweberthomas arachidonicacidmetabolitesincardiovascularandmetabolicdiseases
AT pizzinialex arachidonicacidmetabolitesincardiovascularandmetabolicdiseases
AT nairzmanfred arachidonicacidmetabolitesincardiovascularandmetabolicdiseases
AT weissgunter arachidonicacidmetabolitesincardiovascularandmetabolicdiseases
AT tancevskiivan arachidonicacidmetabolitesincardiovascularandmetabolicdiseases

Ejemplares similares