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AMP-Activated Protein Kinase and Host Defense against Infection

5′-AMP-activated protein kinase (AMPK) plays diverse roles in various physiological and pathological conditions. AMPK is involved in energy metabolism, which is perturbed by infectious stimuli. Indeed, various pathogens modulate AMPK activity, which affects host defenses against infection. In some v...

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Autores principales: Silwal, Prashanta, Kim, Jin Kyung, Yuk, Jae-Min, Jo, Eun-Kyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274990/
https://www.ncbi.nlm.nih.gov/pubmed/30404221
http://dx.doi.org/10.3390/ijms19113495
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author Silwal, Prashanta
Kim, Jin Kyung
Yuk, Jae-Min
Jo, Eun-Kyeong
author_facet Silwal, Prashanta
Kim, Jin Kyung
Yuk, Jae-Min
Jo, Eun-Kyeong
author_sort Silwal, Prashanta
collection PubMed
description 5′-AMP-activated protein kinase (AMPK) plays diverse roles in various physiological and pathological conditions. AMPK is involved in energy metabolism, which is perturbed by infectious stimuli. Indeed, various pathogens modulate AMPK activity, which affects host defenses against infection. In some viral infections, including hepatitis B and C viral infections, AMPK activation is beneficial, but in others such as dengue virus, Ebola virus, and human cytomegaloviral infections, AMPK plays a detrimental role. AMPK-targeting agents or small molecules enhance the antiviral response and contribute to the control of microbial and parasitic infections. In addition, this review focuses on the double-edged role of AMPK in innate and adaptive immune responses to infection. Understanding how AMPK regulates host defenses will enable development of more effective host-directed therapeutic strategies against infectious diseases.
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spelling pubmed-62749902018-12-15 AMP-Activated Protein Kinase and Host Defense against Infection Silwal, Prashanta Kim, Jin Kyung Yuk, Jae-Min Jo, Eun-Kyeong Int J Mol Sci Review 5′-AMP-activated protein kinase (AMPK) plays diverse roles in various physiological and pathological conditions. AMPK is involved in energy metabolism, which is perturbed by infectious stimuli. Indeed, various pathogens modulate AMPK activity, which affects host defenses against infection. In some viral infections, including hepatitis B and C viral infections, AMPK activation is beneficial, but in others such as dengue virus, Ebola virus, and human cytomegaloviral infections, AMPK plays a detrimental role. AMPK-targeting agents or small molecules enhance the antiviral response and contribute to the control of microbial and parasitic infections. In addition, this review focuses on the double-edged role of AMPK in innate and adaptive immune responses to infection. Understanding how AMPK regulates host defenses will enable development of more effective host-directed therapeutic strategies against infectious diseases. MDPI 2018-11-06 /pmc/articles/PMC6274990/ /pubmed/30404221 http://dx.doi.org/10.3390/ijms19113495 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Silwal, Prashanta
Kim, Jin Kyung
Yuk, Jae-Min
Jo, Eun-Kyeong
AMP-Activated Protein Kinase and Host Defense against Infection
title AMP-Activated Protein Kinase and Host Defense against Infection
title_full AMP-Activated Protein Kinase and Host Defense against Infection
title_fullStr AMP-Activated Protein Kinase and Host Defense against Infection
title_full_unstemmed AMP-Activated Protein Kinase and Host Defense against Infection
title_short AMP-Activated Protein Kinase and Host Defense against Infection
title_sort amp-activated protein kinase and host defense against infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274990/
https://www.ncbi.nlm.nih.gov/pubmed/30404221
http://dx.doi.org/10.3390/ijms19113495
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