Cargando…
AMP-Activated Protein Kinase and Host Defense against Infection
5′-AMP-activated protein kinase (AMPK) plays diverse roles in various physiological and pathological conditions. AMPK is involved in energy metabolism, which is perturbed by infectious stimuli. Indeed, various pathogens modulate AMPK activity, which affects host defenses against infection. In some v...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274990/ https://www.ncbi.nlm.nih.gov/pubmed/30404221 http://dx.doi.org/10.3390/ijms19113495 |
_version_ | 1783377736164704256 |
---|---|
author | Silwal, Prashanta Kim, Jin Kyung Yuk, Jae-Min Jo, Eun-Kyeong |
author_facet | Silwal, Prashanta Kim, Jin Kyung Yuk, Jae-Min Jo, Eun-Kyeong |
author_sort | Silwal, Prashanta |
collection | PubMed |
description | 5′-AMP-activated protein kinase (AMPK) plays diverse roles in various physiological and pathological conditions. AMPK is involved in energy metabolism, which is perturbed by infectious stimuli. Indeed, various pathogens modulate AMPK activity, which affects host defenses against infection. In some viral infections, including hepatitis B and C viral infections, AMPK activation is beneficial, but in others such as dengue virus, Ebola virus, and human cytomegaloviral infections, AMPK plays a detrimental role. AMPK-targeting agents or small molecules enhance the antiviral response and contribute to the control of microbial and parasitic infections. In addition, this review focuses on the double-edged role of AMPK in innate and adaptive immune responses to infection. Understanding how AMPK regulates host defenses will enable development of more effective host-directed therapeutic strategies against infectious diseases. |
format | Online Article Text |
id | pubmed-6274990 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62749902018-12-15 AMP-Activated Protein Kinase and Host Defense against Infection Silwal, Prashanta Kim, Jin Kyung Yuk, Jae-Min Jo, Eun-Kyeong Int J Mol Sci Review 5′-AMP-activated protein kinase (AMPK) plays diverse roles in various physiological and pathological conditions. AMPK is involved in energy metabolism, which is perturbed by infectious stimuli. Indeed, various pathogens modulate AMPK activity, which affects host defenses against infection. In some viral infections, including hepatitis B and C viral infections, AMPK activation is beneficial, but in others such as dengue virus, Ebola virus, and human cytomegaloviral infections, AMPK plays a detrimental role. AMPK-targeting agents or small molecules enhance the antiviral response and contribute to the control of microbial and parasitic infections. In addition, this review focuses on the double-edged role of AMPK in innate and adaptive immune responses to infection. Understanding how AMPK regulates host defenses will enable development of more effective host-directed therapeutic strategies against infectious diseases. MDPI 2018-11-06 /pmc/articles/PMC6274990/ /pubmed/30404221 http://dx.doi.org/10.3390/ijms19113495 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Silwal, Prashanta Kim, Jin Kyung Yuk, Jae-Min Jo, Eun-Kyeong AMP-Activated Protein Kinase and Host Defense against Infection |
title | AMP-Activated Protein Kinase and Host Defense against Infection |
title_full | AMP-Activated Protein Kinase and Host Defense against Infection |
title_fullStr | AMP-Activated Protein Kinase and Host Defense against Infection |
title_full_unstemmed | AMP-Activated Protein Kinase and Host Defense against Infection |
title_short | AMP-Activated Protein Kinase and Host Defense against Infection |
title_sort | amp-activated protein kinase and host defense against infection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274990/ https://www.ncbi.nlm.nih.gov/pubmed/30404221 http://dx.doi.org/10.3390/ijms19113495 |
work_keys_str_mv | AT silwalprashanta ampactivatedproteinkinaseandhostdefenseagainstinfection AT kimjinkyung ampactivatedproteinkinaseandhostdefenseagainstinfection AT yukjaemin ampactivatedproteinkinaseandhostdefenseagainstinfection AT joeunkyeong ampactivatedproteinkinaseandhostdefenseagainstinfection |