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Key Immunological Functions Involved in the Progression of Epithelial Ovarian Serous Carcinoma Discovered by the Gene Ontology-Based Immunofunctionome Analysis

Serous carcinoma (SC) is the most common and lethal subtype of epithelial ovarian carcinoma; immunotherapy is a potential treatment for SC, however, the global immunological functions of SC as well as their change during the progression of SC have not been investigated in detail till now. We conduct...

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Autores principales: Chang, Cheng-Chang, Su, Kuo-Min, Lu, Kai-Hsi, Lin, Chi-Kang, Wang, Peng-Hui, Li, Hsin-Yang, Wang, Mong-Lien, Lin, Cheng-Kuo, Yu, Mu-Hsien, Chang, Chia-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274992/
https://www.ncbi.nlm.nih.gov/pubmed/30356023
http://dx.doi.org/10.3390/ijms19113311
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author Chang, Cheng-Chang
Su, Kuo-Min
Lu, Kai-Hsi
Lin, Chi-Kang
Wang, Peng-Hui
Li, Hsin-Yang
Wang, Mong-Lien
Lin, Cheng-Kuo
Yu, Mu-Hsien
Chang, Chia-Ming
author_facet Chang, Cheng-Chang
Su, Kuo-Min
Lu, Kai-Hsi
Lin, Chi-Kang
Wang, Peng-Hui
Li, Hsin-Yang
Wang, Mong-Lien
Lin, Cheng-Kuo
Yu, Mu-Hsien
Chang, Chia-Ming
author_sort Chang, Cheng-Chang
collection PubMed
description Serous carcinoma (SC) is the most common and lethal subtype of epithelial ovarian carcinoma; immunotherapy is a potential treatment for SC, however, the global immunological functions of SC as well as their change during the progression of SC have not been investigated in detail till now. We conducted a genome-wide integrative analysis to investigate the immunofunctionomes of SC at four tumor stages by quantifying the immunological functions defined by the Gene Ontology gene sets. DNA microarray gene expression profiles of 1100 SCs and 136 normal ovarian tissue controls were downloaded from the Gene Expression Omnibus database and converted to the functionome. Then the immunofunctionomes were reconstructed by extracting the offspring from the functionome for the four SC staging groups. The key immunological functions extracted from immunofunctionomes with a series of filters revealed that the immunopathy of SC consisted of a group of deregulated functions with the core members including B cell activation and differentiation, regulation of leukocyte chemotaxis/cellular extravasation, antigen receptor mediated signaling pathway, T helper mediated immunity and macrophage activation; and the auxiliary elements included leukocyte mediated immunity, regulation of inflammatory response, T cell differentiation, mononuclear cell migration, megakaryocyte differentiation, complement activation and cytokine production. These deregulated immunological functions reveal the candidates to target in the immunotherapy.
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spelling pubmed-62749922018-12-15 Key Immunological Functions Involved in the Progression of Epithelial Ovarian Serous Carcinoma Discovered by the Gene Ontology-Based Immunofunctionome Analysis Chang, Cheng-Chang Su, Kuo-Min Lu, Kai-Hsi Lin, Chi-Kang Wang, Peng-Hui Li, Hsin-Yang Wang, Mong-Lien Lin, Cheng-Kuo Yu, Mu-Hsien Chang, Chia-Ming Int J Mol Sci Article Serous carcinoma (SC) is the most common and lethal subtype of epithelial ovarian carcinoma; immunotherapy is a potential treatment for SC, however, the global immunological functions of SC as well as their change during the progression of SC have not been investigated in detail till now. We conducted a genome-wide integrative analysis to investigate the immunofunctionomes of SC at four tumor stages by quantifying the immunological functions defined by the Gene Ontology gene sets. DNA microarray gene expression profiles of 1100 SCs and 136 normal ovarian tissue controls were downloaded from the Gene Expression Omnibus database and converted to the functionome. Then the immunofunctionomes were reconstructed by extracting the offspring from the functionome for the four SC staging groups. The key immunological functions extracted from immunofunctionomes with a series of filters revealed that the immunopathy of SC consisted of a group of deregulated functions with the core members including B cell activation and differentiation, regulation of leukocyte chemotaxis/cellular extravasation, antigen receptor mediated signaling pathway, T helper mediated immunity and macrophage activation; and the auxiliary elements included leukocyte mediated immunity, regulation of inflammatory response, T cell differentiation, mononuclear cell migration, megakaryocyte differentiation, complement activation and cytokine production. These deregulated immunological functions reveal the candidates to target in the immunotherapy. MDPI 2018-10-24 /pmc/articles/PMC6274992/ /pubmed/30356023 http://dx.doi.org/10.3390/ijms19113311 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chang, Cheng-Chang
Su, Kuo-Min
Lu, Kai-Hsi
Lin, Chi-Kang
Wang, Peng-Hui
Li, Hsin-Yang
Wang, Mong-Lien
Lin, Cheng-Kuo
Yu, Mu-Hsien
Chang, Chia-Ming
Key Immunological Functions Involved in the Progression of Epithelial Ovarian Serous Carcinoma Discovered by the Gene Ontology-Based Immunofunctionome Analysis
title Key Immunological Functions Involved in the Progression of Epithelial Ovarian Serous Carcinoma Discovered by the Gene Ontology-Based Immunofunctionome Analysis
title_full Key Immunological Functions Involved in the Progression of Epithelial Ovarian Serous Carcinoma Discovered by the Gene Ontology-Based Immunofunctionome Analysis
title_fullStr Key Immunological Functions Involved in the Progression of Epithelial Ovarian Serous Carcinoma Discovered by the Gene Ontology-Based Immunofunctionome Analysis
title_full_unstemmed Key Immunological Functions Involved in the Progression of Epithelial Ovarian Serous Carcinoma Discovered by the Gene Ontology-Based Immunofunctionome Analysis
title_short Key Immunological Functions Involved in the Progression of Epithelial Ovarian Serous Carcinoma Discovered by the Gene Ontology-Based Immunofunctionome Analysis
title_sort key immunological functions involved in the progression of epithelial ovarian serous carcinoma discovered by the gene ontology-based immunofunctionome analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274992/
https://www.ncbi.nlm.nih.gov/pubmed/30356023
http://dx.doi.org/10.3390/ijms19113311
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