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Structural Studies of the 3′,3′-cGAMP Riboswitch Induced by Cognate and Noncognate Ligands Using Molecular Dynamics Simulation

Riboswtich RNAs can control gene expression through the structural change induced by the corresponding small-molecule ligands. Molecular dynamics simulations and free energy calculations on the aptamer domain of the 3′,3′-cGAMP riboswitch in the ligand-free, cognate-bound and noncognate-bound states...

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Detalles Bibliográficos
Autores principales:	Li, Chaoqun, Zhao, Xiaojia, Zhu, Xiaomin, Xie, Pengtao, Chen, Guangju
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274999/ https://www.ncbi.nlm.nih.gov/pubmed/30423927 http://dx.doi.org/10.3390/ijms19113527

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