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Immune Evasion, a Potential Mechanism of Trichothecenes: New Insights into Negative Immune Regulations

Days ago, the Nobel Prize in Physiology or Medicine 2018 was awarded jointly to James P. Allison and Tasuku Honjo “for their discovery of cancer therapy by inhibition of negative immune regulation”. This news has increased the attention on immunotoxicity and immune evasion mechanisms, which are once...

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Detalles Bibliográficos
Autores principales: Wu, Qinghua, Wu, Wenda, Franca, Tanos C. C., Jacevic, Vesna, Wang, Xu, Kuca, Kamil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275004/
https://www.ncbi.nlm.nih.gov/pubmed/30355984
http://dx.doi.org/10.3390/ijms19113307
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author Wu, Qinghua
Wu, Wenda
Franca, Tanos C. C.
Jacevic, Vesna
Wang, Xu
Kuca, Kamil
author_facet Wu, Qinghua
Wu, Wenda
Franca, Tanos C. C.
Jacevic, Vesna
Wang, Xu
Kuca, Kamil
author_sort Wu, Qinghua
collection PubMed
description Days ago, the Nobel Prize in Physiology or Medicine 2018 was awarded jointly to James P. Allison and Tasuku Honjo “for their discovery of cancer therapy by inhibition of negative immune regulation”. This news has increased the attention on immunotoxicity and immune evasion mechanisms, which are once again hot research topics. Actually, increasing lines of evidence show that trichothecene mycotoxins have a strong immunosuppressive effect. These mycotoxins suppress the host immunity and make them more sensitive to the infection of pathogens, including bacteria and viruses. However, the underlying mechanism(s) in this context is still poorly understood. Interestingly, recent work showed that an immune evasion mechanism might be involved in trichothecene immunotoxicity. In this work, we discuss the potential immune evasion mechanism in trichothecene immunotoxicity. More importantly, under these circumstances, we are pleased to compile a Special Issue entitled “Biochemistry, Molecular Biology, and Toxicology of Natural and Synthetic Toxins” for the International Journal of Molecular Sciences (IJMS). Researchers are encouraged to share their latest interesting findings with the readers of IJMS.
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spelling pubmed-62750042018-12-15 Immune Evasion, a Potential Mechanism of Trichothecenes: New Insights into Negative Immune Regulations Wu, Qinghua Wu, Wenda Franca, Tanos C. C. Jacevic, Vesna Wang, Xu Kuca, Kamil Int J Mol Sci Editorial Days ago, the Nobel Prize in Physiology or Medicine 2018 was awarded jointly to James P. Allison and Tasuku Honjo “for their discovery of cancer therapy by inhibition of negative immune regulation”. This news has increased the attention on immunotoxicity and immune evasion mechanisms, which are once again hot research topics. Actually, increasing lines of evidence show that trichothecene mycotoxins have a strong immunosuppressive effect. These mycotoxins suppress the host immunity and make them more sensitive to the infection of pathogens, including bacteria and viruses. However, the underlying mechanism(s) in this context is still poorly understood. Interestingly, recent work showed that an immune evasion mechanism might be involved in trichothecene immunotoxicity. In this work, we discuss the potential immune evasion mechanism in trichothecene immunotoxicity. More importantly, under these circumstances, we are pleased to compile a Special Issue entitled “Biochemistry, Molecular Biology, and Toxicology of Natural and Synthetic Toxins” for the International Journal of Molecular Sciences (IJMS). Researchers are encouraged to share their latest interesting findings with the readers of IJMS. MDPI 2018-10-24 /pmc/articles/PMC6275004/ /pubmed/30355984 http://dx.doi.org/10.3390/ijms19113307 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Editorial
Wu, Qinghua
Wu, Wenda
Franca, Tanos C. C.
Jacevic, Vesna
Wang, Xu
Kuca, Kamil
Immune Evasion, a Potential Mechanism of Trichothecenes: New Insights into Negative Immune Regulations
title Immune Evasion, a Potential Mechanism of Trichothecenes: New Insights into Negative Immune Regulations
title_full Immune Evasion, a Potential Mechanism of Trichothecenes: New Insights into Negative Immune Regulations
title_fullStr Immune Evasion, a Potential Mechanism of Trichothecenes: New Insights into Negative Immune Regulations
title_full_unstemmed Immune Evasion, a Potential Mechanism of Trichothecenes: New Insights into Negative Immune Regulations
title_short Immune Evasion, a Potential Mechanism of Trichothecenes: New Insights into Negative Immune Regulations
title_sort immune evasion, a potential mechanism of trichothecenes: new insights into negative immune regulations
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275004/
https://www.ncbi.nlm.nih.gov/pubmed/30355984
http://dx.doi.org/10.3390/ijms19113307
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