Cargando…

Adipose Stem Cell Translational Applications: From Bench-to-Bedside

During the last five years, there has been a significantly increasing interest in adult adipose stem cells (ASCs) as a suitable tool for translational medicine applications. The abundant and renewable source of ASCs and the relatively simple procedure for cell isolation are only some of the reasons...

Descripción completa

Detalles Bibliográficos
Autores principales: Argentati, Chiara, Morena, Francesco, Bazzucchi, Martina, Armentano, Ilaria, Emiliani, Carla, Martino, Sabata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275042/
https://www.ncbi.nlm.nih.gov/pubmed/30400641
http://dx.doi.org/10.3390/ijms19113475
_version_ 1783377748706721792
author Argentati, Chiara
Morena, Francesco
Bazzucchi, Martina
Armentano, Ilaria
Emiliani, Carla
Martino, Sabata
author_facet Argentati, Chiara
Morena, Francesco
Bazzucchi, Martina
Armentano, Ilaria
Emiliani, Carla
Martino, Sabata
author_sort Argentati, Chiara
collection PubMed
description During the last five years, there has been a significantly increasing interest in adult adipose stem cells (ASCs) as a suitable tool for translational medicine applications. The abundant and renewable source of ASCs and the relatively simple procedure for cell isolation are only some of the reasons for this success. Here, we document the advances in the biology and in the innovative biotechnological applications of ASCs. We discuss how the multipotential property boosts ASCs toward mesenchymal and non-mesenchymal differentiation cell lineages and how their character is maintained even if they are combined with gene delivery systems and/or biomaterials, both in vitro and in vivo.
format Online
Article
Text
id pubmed-6275042
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62750422018-12-15 Adipose Stem Cell Translational Applications: From Bench-to-Bedside Argentati, Chiara Morena, Francesco Bazzucchi, Martina Armentano, Ilaria Emiliani, Carla Martino, Sabata Int J Mol Sci Review During the last five years, there has been a significantly increasing interest in adult adipose stem cells (ASCs) as a suitable tool for translational medicine applications. The abundant and renewable source of ASCs and the relatively simple procedure for cell isolation are only some of the reasons for this success. Here, we document the advances in the biology and in the innovative biotechnological applications of ASCs. We discuss how the multipotential property boosts ASCs toward mesenchymal and non-mesenchymal differentiation cell lineages and how their character is maintained even if they are combined with gene delivery systems and/or biomaterials, both in vitro and in vivo. MDPI 2018-11-05 /pmc/articles/PMC6275042/ /pubmed/30400641 http://dx.doi.org/10.3390/ijms19113475 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Argentati, Chiara
Morena, Francesco
Bazzucchi, Martina
Armentano, Ilaria
Emiliani, Carla
Martino, Sabata
Adipose Stem Cell Translational Applications: From Bench-to-Bedside
title Adipose Stem Cell Translational Applications: From Bench-to-Bedside
title_full Adipose Stem Cell Translational Applications: From Bench-to-Bedside
title_fullStr Adipose Stem Cell Translational Applications: From Bench-to-Bedside
title_full_unstemmed Adipose Stem Cell Translational Applications: From Bench-to-Bedside
title_short Adipose Stem Cell Translational Applications: From Bench-to-Bedside
title_sort adipose stem cell translational applications: from bench-to-bedside
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275042/
https://www.ncbi.nlm.nih.gov/pubmed/30400641
http://dx.doi.org/10.3390/ijms19113475
work_keys_str_mv AT argentatichiara adiposestemcelltranslationalapplicationsfrombenchtobedside
AT morenafrancesco adiposestemcelltranslationalapplicationsfrombenchtobedside
AT bazzucchimartina adiposestemcelltranslationalapplicationsfrombenchtobedside
AT armentanoilaria adiposestemcelltranslationalapplicationsfrombenchtobedside
AT emilianicarla adiposestemcelltranslationalapplicationsfrombenchtobedside
AT martinosabata adiposestemcelltranslationalapplicationsfrombenchtobedside