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The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease of unknown etiology and dismal prognosis. IPF patients are known to have an increased risk of lung cancer and careful decision-making is required for the treatment of lung cancer associated with IPF. Transforming growth facto...

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Detalles Bibliográficos
Autores principales: Saito, Akira, Horie, Masafumi, Micke, Patrick, Nagase, Takahide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275044/
https://www.ncbi.nlm.nih.gov/pubmed/30445777
http://dx.doi.org/10.3390/ijms19113611
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author Saito, Akira
Horie, Masafumi
Micke, Patrick
Nagase, Takahide
author_facet Saito, Akira
Horie, Masafumi
Micke, Patrick
Nagase, Takahide
author_sort Saito, Akira
collection PubMed
description Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease of unknown etiology and dismal prognosis. IPF patients are known to have an increased risk of lung cancer and careful decision-making is required for the treatment of lung cancer associated with IPF. Transforming growth factor (TGF)-β signaling plays a central role in tissue fibrosis and tumorigenesis. TGF-β-mediated pathological changes that occur in IPF lung tissue may promote the process of field cancerization and provide the microenvironment favorable to cancer initiation and progression. This review summarizes the current knowledge related to IPF pathogenesis and explores the molecular mechanisms that underlie the occurrence of lung cancer in the background of IPF, with an emphasis on the multifaceted effects of TGF-β signaling.
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spelling pubmed-62750442018-12-15 The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis Saito, Akira Horie, Masafumi Micke, Patrick Nagase, Takahide Int J Mol Sci Review Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease of unknown etiology and dismal prognosis. IPF patients are known to have an increased risk of lung cancer and careful decision-making is required for the treatment of lung cancer associated with IPF. Transforming growth factor (TGF)-β signaling plays a central role in tissue fibrosis and tumorigenesis. TGF-β-mediated pathological changes that occur in IPF lung tissue may promote the process of field cancerization and provide the microenvironment favorable to cancer initiation and progression. This review summarizes the current knowledge related to IPF pathogenesis and explores the molecular mechanisms that underlie the occurrence of lung cancer in the background of IPF, with an emphasis on the multifaceted effects of TGF-β signaling. MDPI 2018-11-15 /pmc/articles/PMC6275044/ /pubmed/30445777 http://dx.doi.org/10.3390/ijms19113611 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Saito, Akira
Horie, Masafumi
Micke, Patrick
Nagase, Takahide
The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis
title The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis
title_full The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis
title_fullStr The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis
title_full_unstemmed The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis
title_short The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis
title_sort role of tgf-β signaling in lung cancer associated with idiopathic pulmonary fibrosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275044/
https://www.ncbi.nlm.nih.gov/pubmed/30445777
http://dx.doi.org/10.3390/ijms19113611
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