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Programming of Vascular Dysfunction in the Intrauterine Milieu of Diabetic Pregnancies

With the rising global tide of obesity, gestational diabetes mellitus (GDM) burgeoned into one of the most common antenatal disorders worldwide. Macrosomic babies born to diabetic mothers are more likely to develop risk factors for cardiovascular disease (CVD) before they reach adulthood. Rodent stu...

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Autores principales: Sallam, Nada A., Palmgren, Victoria A. C., Singh, Radha D., John, Cini M., Thompson, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275067/
https://www.ncbi.nlm.nih.gov/pubmed/30463313
http://dx.doi.org/10.3390/ijms19113665
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author Sallam, Nada A.
Palmgren, Victoria A. C.
Singh, Radha D.
John, Cini M.
Thompson, Jennifer A.
author_facet Sallam, Nada A.
Palmgren, Victoria A. C.
Singh, Radha D.
John, Cini M.
Thompson, Jennifer A.
author_sort Sallam, Nada A.
collection PubMed
description With the rising global tide of obesity, gestational diabetes mellitus (GDM) burgeoned into one of the most common antenatal disorders worldwide. Macrosomic babies born to diabetic mothers are more likely to develop risk factors for cardiovascular disease (CVD) before they reach adulthood. Rodent studies in offspring born to hyperglycemic pregnancies show vascular dysfunction characterized by impaired nitric oxide (NO)-mediated vasodilation and increased production of contractile prostanoids by cyclooxygenase 2 (COX-2). Vascular dysfunction is a key pathogenic event in the progression of diabetes-related vascular disease, primarily attributable to glucotoxicity. Therefore, glucose-induced vascular injury may stem directly from the hyperglycemic intrauterine environment of GDM pregnancy, as evinced by studies showing endothelial activation and inflammation at birth or in childhood in offspring born to GDM mothers. This review discusses potential mechanisms by which intrauterine hyperglycemia programs dysfunction in the developing vasculature.
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spelling pubmed-62750672018-12-15 Programming of Vascular Dysfunction in the Intrauterine Milieu of Diabetic Pregnancies Sallam, Nada A. Palmgren, Victoria A. C. Singh, Radha D. John, Cini M. Thompson, Jennifer A. Int J Mol Sci Review With the rising global tide of obesity, gestational diabetes mellitus (GDM) burgeoned into one of the most common antenatal disorders worldwide. Macrosomic babies born to diabetic mothers are more likely to develop risk factors for cardiovascular disease (CVD) before they reach adulthood. Rodent studies in offspring born to hyperglycemic pregnancies show vascular dysfunction characterized by impaired nitric oxide (NO)-mediated vasodilation and increased production of contractile prostanoids by cyclooxygenase 2 (COX-2). Vascular dysfunction is a key pathogenic event in the progression of diabetes-related vascular disease, primarily attributable to glucotoxicity. Therefore, glucose-induced vascular injury may stem directly from the hyperglycemic intrauterine environment of GDM pregnancy, as evinced by studies showing endothelial activation and inflammation at birth or in childhood in offspring born to GDM mothers. This review discusses potential mechanisms by which intrauterine hyperglycemia programs dysfunction in the developing vasculature. MDPI 2018-11-20 /pmc/articles/PMC6275067/ /pubmed/30463313 http://dx.doi.org/10.3390/ijms19113665 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sallam, Nada A.
Palmgren, Victoria A. C.
Singh, Radha D.
John, Cini M.
Thompson, Jennifer A.
Programming of Vascular Dysfunction in the Intrauterine Milieu of Diabetic Pregnancies
title Programming of Vascular Dysfunction in the Intrauterine Milieu of Diabetic Pregnancies
title_full Programming of Vascular Dysfunction in the Intrauterine Milieu of Diabetic Pregnancies
title_fullStr Programming of Vascular Dysfunction in the Intrauterine Milieu of Diabetic Pregnancies
title_full_unstemmed Programming of Vascular Dysfunction in the Intrauterine Milieu of Diabetic Pregnancies
title_short Programming of Vascular Dysfunction in the Intrauterine Milieu of Diabetic Pregnancies
title_sort programming of vascular dysfunction in the intrauterine milieu of diabetic pregnancies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275067/
https://www.ncbi.nlm.nih.gov/pubmed/30463313
http://dx.doi.org/10.3390/ijms19113665
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