Activated Integrated Stress Response Induced by Salubrinal Promotes Cisplatin Resistance in Human Gastric Cancer Cells via Enhanced xCT Expression and Glutathione Biosynthesis

The integrated stress response (ISR) pathway is essential for adaption of various stresses and is related to mitochondrion-to-nucleus communication. Mitochondrial dysfunction-induced reactive oxygen species (ROS) was demonstrated to activate general control nonderepressible 2 (GCN2)–eukaryotic trans...

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Detalles Bibliográficos
Autores principales: Wang, Sheng-Fan, Wung, Chih-Hsuan, Chen, Meng-Shian, Chen, Chian-Feng, Yin, Pen-Hui, Yeh, Tien-Shun, Chang, Yuh-Lih, Chou, Yueh-Ching, Hung, Hung-Hsu, Lee, Hsin-Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275069/
https://www.ncbi.nlm.nih.gov/pubmed/30380689
http://dx.doi.org/10.3390/ijms19113389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275069/
https://www.ncbi.nlm.nih.gov/pubmed/30380689
http://dx.doi.org/10.3390/ijms19113389

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