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Oncogenic microRNA signature for early diagnosis of cervical intraepithelial neoplasia and cancer

Cervical cancer is one of the leading causes of cancer death in women globally, despite the widespread use of cytology/human papillomavirus (HPV) screening. In the present study, we aimed to identify the potential role of microRNA (miRNA) as a diagnostic biomarker in the detection of cervical pre‐ma...

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Autores principales: Liu, Stephanie S., Chan, Karen K. L., Chu, Daniel K. H., Wei, Tina N., Lau, Lesley S. K., Ngu, Siew F., Chu, Mandy M. Y., Tse, Ka Yu, Ip, Philip P. C., Ng, Enders K. O., Cheung, Annie N. Y., Ngan, Hextan Y. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275249/
https://www.ncbi.nlm.nih.gov/pubmed/30221475
http://dx.doi.org/10.1002/1878-0261.12383
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author Liu, Stephanie S.
Chan, Karen K. L.
Chu, Daniel K. H.
Wei, Tina N.
Lau, Lesley S. K.
Ngu, Siew F.
Chu, Mandy M. Y.
Tse, Ka Yu
Ip, Philip P. C.
Ng, Enders K. O.
Cheung, Annie N. Y.
Ngan, Hextan Y. S.
author_facet Liu, Stephanie S.
Chan, Karen K. L.
Chu, Daniel K. H.
Wei, Tina N.
Lau, Lesley S. K.
Ngu, Siew F.
Chu, Mandy M. Y.
Tse, Ka Yu
Ip, Philip P. C.
Ng, Enders K. O.
Cheung, Annie N. Y.
Ngan, Hextan Y. S.
author_sort Liu, Stephanie S.
collection PubMed
description Cervical cancer is one of the leading causes of cancer death in women globally, despite the widespread use of cytology/human papillomavirus (HPV) screening. In the present study, we aimed to identify the potential role of microRNA (miRNA) as a diagnostic biomarker in the detection of cervical pre‐malignant lesions and cancer. In total, we recruited 582 patients with cervical diseases and 145 control individuals. The expression levels of six miRNAs (miR‐20a, miR‐92a, miR‐141, miR‐183*, miR‐210 and miR‐944) were found to be significantly up‐regulated in cervical cancer and pre‐malignant lesions compared to normal cervical samples, indicating that they are oncogenic miRNAs. Receiver operating characteristic curve analysis showed that these six miRNAs can be used to distinguish patients with cervical pre‐malignant lesions or cancer from normal individuals and they also had a good predictive performance, particularly in cervical lesions. Combined use of these six miRNAs further enhanced the diagnostic accuracy over any single miRNA marker, with an area under the curve of 0.998, 0.996 and 0.959, a diagnostic sensitivity of 97.9%, 97.2% and 91.4%, and a specificity of 98.6%, 96.6% and 87.6% for low‐grade lesions, high‐grade lesions and cancer, respectively. This six oncogenic miRNA signature may be suitable for use as diagnostic marker for cervical pre‐malignant lesions and cancer in the near future.
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spelling pubmed-62752492018-12-05 Oncogenic microRNA signature for early diagnosis of cervical intraepithelial neoplasia and cancer Liu, Stephanie S. Chan, Karen K. L. Chu, Daniel K. H. Wei, Tina N. Lau, Lesley S. K. Ngu, Siew F. Chu, Mandy M. Y. Tse, Ka Yu Ip, Philip P. C. Ng, Enders K. O. Cheung, Annie N. Y. Ngan, Hextan Y. S. Mol Oncol Research Articles Cervical cancer is one of the leading causes of cancer death in women globally, despite the widespread use of cytology/human papillomavirus (HPV) screening. In the present study, we aimed to identify the potential role of microRNA (miRNA) as a diagnostic biomarker in the detection of cervical pre‐malignant lesions and cancer. In total, we recruited 582 patients with cervical diseases and 145 control individuals. The expression levels of six miRNAs (miR‐20a, miR‐92a, miR‐141, miR‐183*, miR‐210 and miR‐944) were found to be significantly up‐regulated in cervical cancer and pre‐malignant lesions compared to normal cervical samples, indicating that they are oncogenic miRNAs. Receiver operating characteristic curve analysis showed that these six miRNAs can be used to distinguish patients with cervical pre‐malignant lesions or cancer from normal individuals and they also had a good predictive performance, particularly in cervical lesions. Combined use of these six miRNAs further enhanced the diagnostic accuracy over any single miRNA marker, with an area under the curve of 0.998, 0.996 and 0.959, a diagnostic sensitivity of 97.9%, 97.2% and 91.4%, and a specificity of 98.6%, 96.6% and 87.6% for low‐grade lesions, high‐grade lesions and cancer, respectively. This six oncogenic miRNA signature may be suitable for use as diagnostic marker for cervical pre‐malignant lesions and cancer in the near future. John Wiley and Sons Inc. 2018-09-27 2018-12 /pmc/articles/PMC6275249/ /pubmed/30221475 http://dx.doi.org/10.1002/1878-0261.12383 Text en © 2018 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Liu, Stephanie S.
Chan, Karen K. L.
Chu, Daniel K. H.
Wei, Tina N.
Lau, Lesley S. K.
Ngu, Siew F.
Chu, Mandy M. Y.
Tse, Ka Yu
Ip, Philip P. C.
Ng, Enders K. O.
Cheung, Annie N. Y.
Ngan, Hextan Y. S.
Oncogenic microRNA signature for early diagnosis of cervical intraepithelial neoplasia and cancer
title Oncogenic microRNA signature for early diagnosis of cervical intraepithelial neoplasia and cancer
title_full Oncogenic microRNA signature for early diagnosis of cervical intraepithelial neoplasia and cancer
title_fullStr Oncogenic microRNA signature for early diagnosis of cervical intraepithelial neoplasia and cancer
title_full_unstemmed Oncogenic microRNA signature for early diagnosis of cervical intraepithelial neoplasia and cancer
title_short Oncogenic microRNA signature for early diagnosis of cervical intraepithelial neoplasia and cancer
title_sort oncogenic microrna signature for early diagnosis of cervical intraepithelial neoplasia and cancer
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275249/
https://www.ncbi.nlm.nih.gov/pubmed/30221475
http://dx.doi.org/10.1002/1878-0261.12383
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