Cargando…

Inhibitors of BMP‐1/tolloid‐like proteinases: efficacy, selectivity and cellular toxicity

BMP‐1/tolloid‐like proteinases belong to the astacin family of human metalloproteinases, together with meprins and ovastacin. They represent promising targets to treat or prevent a wide range of diseases such as fibrotic disorders or cancer. However, the study of their pathophysiological roles is st...

Descripción completa

Detalles Bibliográficos
Autores principales:	Talantikite, Maya, Lécorché, Pascaline, Beau, Fabrice, Damour, Odile, Becker‐Pauly, Christoph, Ho, Wen‐Bin, Dive, Vincent, Vadon‐Le Goff, Sandrine, Moali, Catherine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275283/ https://www.ncbi.nlm.nih.gov/pubmed/30524951 http://dx.doi.org/10.1002/2211-5463.12540

Ejemplares similares

Identification of PCPE-2 as the endogenous specific inhibitor of human BMP-1/tolloid-like proteinases
por: Vadon-Le Goff, Sandrine, et al.
Publicado: (2023)

Interaction of Complement Defence Collagens C1q and Mannose-Binding Lectin with BMP-1/Tolloid-like Proteinases
por: Lacroix, Monique, et al.
Publicado: (2017)

Procollagen C-proteinase enhancer-1 (PCPE-1), a potential biomarker and therapeutic target for fibrosis
por: Lagoutte, Priscillia, et al.
Publicado: (2021)

Mammalian tolloid proteinases: role in growth factor signalling
por: Troilo, Helen, et al.
Publicado: (2016)

Structural Basis for the Acceleration of Procollagen Processing by Procollagen C-Proteinase Enhancer-1
por: Pulido, David, et al.
Publicado: (2018)

Procollagen C-proteinase Enhancer Stimulates Procollagen Processing by Binding to the C-propeptide Region Only
por: Vadon-Le Goff, Sandrine, et al.
Publicado: (2011)

Diversity between mammalian tolloid proteinases: Oligomerisation and non-catalytic domains influence activity and specificity
por: Bayley, Christopher P., et al.
Publicado: (2016)

The role of chordin fragments generated by partial tolloid cleavage in regulating BMP activity
por: Troilo, Helen, et al.
Publicado: (2015)

Role of the Netrin-like Domain of Procollagen C-Proteinase Enhancer-1 in the Control of Metalloproteinase Activity
por: Bekhouche, Mourad, et al.
Publicado: (2010)

Structural and functional evidence for a substrate exclusion mechanism in mammalian tolloid like-1 (TLL-1) proteinase
por: Berry, Richard, et al.
Publicado: (2010)

Dynamics of the secreted frizzled related protein Sizzled and potential implications for binding to bone morphogenetic protein-1 (BMP-1)
por: Sharma, Urvashi, et al.
Publicado: (2022)

Synthetic enzyme-substrate tethering obviates the Tolloid-ECM interaction during Drosophila BMP gradient formation
por: Winstanley, Jennifer, et al.
Publicado: (2015)

Functional and structural studies of tolloid-like 1 mutants associated with atrial-septal defect 6
por: Sieron, Lukasz, et al.
Publicado: (2019)

Structural basis of homo- and heterotrimerization of collagen I
por: Sharma, Urvashi, et al.
Publicado: (2017)

DSP-PP Precursor Protein Cleavage by Tolloid-Related-1 Protein and by Bone Morphogenetic Protein-1
por: Ritchie, Helena H., et al.
Publicado: (2012)

Tolloid-like 1 genetic variants determine fibrosis regression in chronic hepatitis C patients with curative antivirals
por: Huang, Chung-Feng, et al.
Publicado: (2018)

Cellular locations of proteinases and association with vesicles in porphyromonas gingivalis
por: Oishi, S, et al.
Publicado: (2010)

Development of ex vivo organ culture models to mimic human corneal scarring
por: Janin-Manificat, Hélène, et al.
Publicado: (2012)

A Case Control Association Study and Cognitive Function Analysis of Neuropilin and Tolloid-Like 1 Gene and Schizophrenia in the Japanese Population
por: Banno, Masahiro, et al.
Publicado: (2011)

High neuropilin and tolloid‐like 1 expression associated with metastasis and poor survival in epithelial ovarian cancer via regulation of actin cytoskeleton
por: Xu, Yunzhao, et al.
Publicado: (2020)

Proteinases in the joint: clinical relevance of proteinases in joint destruction
por: Rengel, Yvonne, et al.
Publicado: (2007)

Tolloid‐Like 1 Negatively Regulates Hepatic Differentiation of Human Induced Pluripotent Stem Cells Through Transforming Growth Factor Beta Signaling
por: Kiso, Ayumi, et al.
Publicado: (2020)

Proteinases and Tumour Invasion
por: Schor, S.
Publicado: (1982)

Viral cysteine proteinases
por: Gorbalenya, Alexander E., et al.
Publicado: (1996)

PROTEINASE INHIBITORS | Cystatins
por: Pemberton, P.A.
Publicado: (2006)

Synergistic Effect of Proteinase Activity by Purification and Identification of Toxic Protease From Nemopilema nomurai
por: Yu, Chunlin, et al.
Publicado: (2021)

Relationship of proteinases and proteinase inhibitors with microbial presence in chronic lung disease of prematurity
por: Davies, Philip L, et al.
Publicado: (2010)

Positive role of cell wall anchored proteinase PrtP in adhesion of lactococci
por: Habimana, Olivier, et al.
Publicado: (2007)

Tolloid-like 1 gene variant rs17047200, pretreatment FIB-4, ALBI and PALBI scores as predictors of hepatocellular carcinoma occurrence after directly acting antivirals
por: Kamal, Ahmed, et al.
Publicado: (2022)

Expression and partial purification of recombinant tomato ringspot nepovirus 3C-like proteinase: comparison of the activity of the mature proteinase and the VPg-proteinase precursor
por: Chisholm, Joan, et al.
Publicado: (2001)

AN INACTIVE PRECURSOR OF STREPTOCOCCAL PROTEINASE
por: Elliott, Stuart D., et al.
Publicado: (1947)

Translational control by viral proteinases
por: Lloyd, Richard E.
Publicado: (2006)

Cysteine proteinases of microorganisms and viruses
por: Rudenskaya, G. N., et al.
Publicado: (2011)

Differential Inhibition of Helicoverpa armigera (Hubner) Gut Proteinases by Proteinase Inhibitors of Okra and It's Wild Relatives
por: Udamale, Shilpa K., et al.
Publicado: (2013)

Enhanced BMP-2/BMP-4 ratio in patients with peripheral spondyloarthritis and in cytokine- and stretch-stimulated mouse chondrocytes
por: Briolay, Anne, et al.
Publicado: (2020)

Assessment of BMP responses in an in vitro model of acute ethanol toxicity
por: Habeeb, Naila, et al.
Publicado: (2022)

A Compact Viral Processing Proteinase/Ubiquitin Hydrolase from the OTU Family
por: Lombardi, Charlotte, et al.
Publicado: (2013)

The major neutral proteinase of Entamoeba histolytica
Publicado: (1986)

Proteinase Activity of Rat Lymph Nodes
por: Stein, Olga, et al.
Publicado: (1960)

Identifying inhibitors of the SARS coronavirus proteinase
por: Jenwitheesuk, Ekachai, et al.
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_1g6o2fdrq6koa0hl8a8t0hrban