Cargando…
Genomic Analysis of Rhodococcus sp. Br-6, a Bromate Reducing Bacterium Isolated From Soil in Chiba, Japan
Bromate is a byproduct of the ozone disinfection of drinking water. It is a genotoxic carcinogen and causes renal cell tumors in rats. Physicochemical removal of bromate is very difficult, making microbial reduction of bromate to bromide a promising approach to eliminate bromate from water. Rhodococ...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275400/ https://www.ncbi.nlm.nih.gov/pubmed/30510597 http://dx.doi.org/10.7150/jgen.27741 |
_version_ | 1783377807997403136 |
---|---|
author | Ito, Kohei Harada, Masafumi Nakajima, Nobuyoshi Yamamura, Shigeki Tomita, Masaru Suzuki, Haruo Amachi, Seigo |
author_facet | Ito, Kohei Harada, Masafumi Nakajima, Nobuyoshi Yamamura, Shigeki Tomita, Masaru Suzuki, Haruo Amachi, Seigo |
author_sort | Ito, Kohei |
collection | PubMed |
description | Bromate is a byproduct of the ozone disinfection of drinking water. It is a genotoxic carcinogen and causes renal cell tumors in rats. Physicochemical removal of bromate is very difficult, making microbial reduction of bromate to bromide a promising approach to eliminate bromate from water. Rhodococcus sp. Br-6, isolated from soil, can efficiently reduce bromate by using acetate as an electron donor. We determined the draft genome sequence of Rhodococcus sp. Br-6 for the potential practical application of the bromate-reducing bacterium. Core genome phylogeny suggests that the Br-6 strain is most closely related to R. equi. The Br-6 genome contains genes encoding multiple isoforms of diaphorase, previously found to be involved in Br-6-mediated bromate reduction. The genes identified in the present study could be effective targets for experimental studies of microbial bromate reduction in the future. |
format | Online Article Text |
id | pubmed-6275400 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-62754002018-12-03 Genomic Analysis of Rhodococcus sp. Br-6, a Bromate Reducing Bacterium Isolated From Soil in Chiba, Japan Ito, Kohei Harada, Masafumi Nakajima, Nobuyoshi Yamamura, Shigeki Tomita, Masaru Suzuki, Haruo Amachi, Seigo J Genomics Research Paper Bromate is a byproduct of the ozone disinfection of drinking water. It is a genotoxic carcinogen and causes renal cell tumors in rats. Physicochemical removal of bromate is very difficult, making microbial reduction of bromate to bromide a promising approach to eliminate bromate from water. Rhodococcus sp. Br-6, isolated from soil, can efficiently reduce bromate by using acetate as an electron donor. We determined the draft genome sequence of Rhodococcus sp. Br-6 for the potential practical application of the bromate-reducing bacterium. Core genome phylogeny suggests that the Br-6 strain is most closely related to R. equi. The Br-6 genome contains genes encoding multiple isoforms of diaphorase, previously found to be involved in Br-6-mediated bromate reduction. The genes identified in the present study could be effective targets for experimental studies of microbial bromate reduction in the future. Ivyspring International Publisher 2018-11-15 /pmc/articles/PMC6275400/ /pubmed/30510597 http://dx.doi.org/10.7150/jgen.27741 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Ito, Kohei Harada, Masafumi Nakajima, Nobuyoshi Yamamura, Shigeki Tomita, Masaru Suzuki, Haruo Amachi, Seigo Genomic Analysis of Rhodococcus sp. Br-6, a Bromate Reducing Bacterium Isolated From Soil in Chiba, Japan |
title | Genomic Analysis of Rhodococcus sp. Br-6, a Bromate Reducing Bacterium Isolated From Soil in Chiba, Japan |
title_full | Genomic Analysis of Rhodococcus sp. Br-6, a Bromate Reducing Bacterium Isolated From Soil in Chiba, Japan |
title_fullStr | Genomic Analysis of Rhodococcus sp. Br-6, a Bromate Reducing Bacterium Isolated From Soil in Chiba, Japan |
title_full_unstemmed | Genomic Analysis of Rhodococcus sp. Br-6, a Bromate Reducing Bacterium Isolated From Soil in Chiba, Japan |
title_short | Genomic Analysis of Rhodococcus sp. Br-6, a Bromate Reducing Bacterium Isolated From Soil in Chiba, Japan |
title_sort | genomic analysis of rhodococcus sp. br-6, a bromate reducing bacterium isolated from soil in chiba, japan |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275400/ https://www.ncbi.nlm.nih.gov/pubmed/30510597 http://dx.doi.org/10.7150/jgen.27741 |
work_keys_str_mv | AT itokohei genomicanalysisofrhodococcusspbr6abromatereducingbacteriumisolatedfromsoilinchibajapan AT haradamasafumi genomicanalysisofrhodococcusspbr6abromatereducingbacteriumisolatedfromsoilinchibajapan AT nakajimanobuyoshi genomicanalysisofrhodococcusspbr6abromatereducingbacteriumisolatedfromsoilinchibajapan AT yamamurashigeki genomicanalysisofrhodococcusspbr6abromatereducingbacteriumisolatedfromsoilinchibajapan AT tomitamasaru genomicanalysisofrhodococcusspbr6abromatereducingbacteriumisolatedfromsoilinchibajapan AT suzukiharuo genomicanalysisofrhodococcusspbr6abromatereducingbacteriumisolatedfromsoilinchibajapan AT amachiseigo genomicanalysisofrhodococcusspbr6abromatereducingbacteriumisolatedfromsoilinchibajapan |