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Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors

Class IA PI3Ks have many roles in health and disease. The rules that govern intersubunit and receptor associations, however, remain unclear. We engineered mouse lines in which individual endogenous class IA PI3K subunits were C-terminally tagged with 17aa that could be biotinylated in vivo. Using th...

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Detalles Bibliográficos
Autores principales:	Tsolakos, N., Durrant, T. N., Chessa, T., Suire, S. M., Oxley, D., Kulkarni, S., Downward, J., Perisic, O., Williams, R. L., Stephens, L., Hawkins, P. T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2018
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275495/ https://www.ncbi.nlm.nih.gov/pubmed/30442661 http://dx.doi.org/10.1073/pnas.1803446115

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