Cargando…

PPARγ-K107 SUMOylation regulates insulin sensitivity but not adiposity in mice

The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) is a master regulator of adipocyte differentiation and is the target for the insulin-sensitizing thiazolidinedione (TZD) drugs used to treat type 2 diabetes. In cell-based in vitro studies, the transcriptional activity of PPAR...

Descripción completa

Detalles Bibliográficos
Autores principales:	Katafuchi, Takeshi, Holland, William L., Kollipara, Rahul K., Kittler, Ralf, Mangelsdorf, David J., Kliewer, Steven A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2018
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275522/ https://www.ncbi.nlm.nih.gov/pubmed/30420515 http://dx.doi.org/10.1073/pnas.1814522115

Ejemplares similares

An integrated functional genomic analysis identifies the antitumorigenic mechanism of action for PPARγ in lung cancer cells
por: Kollipara, Rahul K., et al.
Publicado: (2014)

PPARγ sumoylation-mediated lipid accumulation in lung cancer
por: Phan, Ai N.H., et al.
Publicado: (2017)

Correction: PPARγ sumoylation-mediated lipid accumulation in lung cancer
por: Phan, Ai N.H., et al.
Publicado: (2019)

Crocin Improves Insulin Sensitivity and Ameliorates Adiposity by Regulating AMPK-CDK5-PPARγ Signaling
por: Fang, Kai, et al.
Publicado: (2020)

Cross-Talk between PPARγ and Insulin Signaling and Modulation of Insulin Sensitivity
por: Leonardini, Anna, et al.
Publicado: (2009)

A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity
por: Tol, Marc J., et al.
Publicado: (2016)

PIAS1 protects against myocardial ischemia-reperfusion injury by stimulating PPARγ SUMOylation
por: Xie, Bo, et al.
Publicado: (2018)

Brain PPARγ Promotes Obesity and is Required for the Insulin–Sensitizing Effect of Thiazolidinediones
por: Lu, Min, et al.
Publicado: (2011)

Selective Tissue Distribution Mediates Tissue-Dependent PPARγ Activation and Insulin Sensitization by INT131, a Selective PPARγ Modulator
por: Xie, Xinni, et al.
Publicado: (2017)

Carbon Monoxide Induced PPARγ SUMOylation and UCP2 Block Inflammatory Gene Expression in Macrophages
por: Haschemi, Arvand, et al.
Publicado: (2011)

Bilirubin Increases Insulin Sensitivity by Regulating Cholesterol Metabolism, Adipokines and PPARγ Levels
por: Liu, Jinfeng, et al.
Publicado: (2015)

Ligand Binding Reduces SUMOylation of the Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation Function 1 (AF1) Domain
por: Diezko, Rolf, et al.
Publicado: (2013)

PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic Rhythms
por: He, Ying, et al.
Publicado: (2022)

TonEBP suppresses adipogenesis and insulin sensitivity by blocking epigenetic transition of PPARγ2
por: Ho Lee, Jun, et al.
Publicado: (2015)

Corrigendum: Bilirubin Increases Insulin Sensitivity by Regulating Cholesterol Metabolism, Adipokines and PPARγ Levels
por: Liu, Jinfeng, et al.
Publicado: (2016)

Selective PPARγ modulator diosmin improves insulin sensitivity and promotes browning of white fat
por: Yu, Jian, et al.
Publicado: (2023)

Zataria multiflora increases insulin sensitivity and PPARγ gene expression in high fructose fed insulin resistant rats
por: Mohammadi, Abbas, et al.
Publicado: (2014)

Regulatory T cells differentiation in visceral adipose tissues contributes to insulin resistance by regulating JAZF‐1/PPAR‐γ pathway
por: Meng, Fanping, et al.
Publicado: (2023)

The Development of INT131 as a Selective PPARγ Modulator: Approach to a Safer Insulin Sensitizer
por: Higgins, Linda S., et al.
Publicado: (2008)

Insulin Sensitizing Pharmacology of Thiazolidinediones Correlates with Mitochondrial Gene Expression rather than Activation of PPARγ
por: Bolten, Charles W., et al.
Publicado: (2007)

Inhibition of a Novel CLK1-THRAP3-PPARγ Axis Improves Insulin Sensitivity
por: Wang, Zhenguo, et al.
Publicado: (2021)

Insulin Sensitization by PPARγ and GLUT-4 Overexpression/Translocation Mediates the Antidiabetic Effect of Plantago australis †
por: Estrada-Soto, Samuel, et al.
Publicado: (2023)

Control of Brown Adipose Tissue Glucose and Lipid Metabolism by PPARγ
por: Festuccia, William T., et al.
Publicado: (2011)

Saroglitazar, a novel PPARα/γ agonist with predominant PPARα activity, shows lipid-lowering and insulin-sensitizing effects in preclinical models
por: Jain, Mukul R, et al.
Publicado: (2015)

Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity
por: Mayoral, Rafael, et al.
Publicado: (2015)

CMHX008, a PPARγ partial agonist, enhances insulin sensitivity with minor influences on bone loss
por: Hou, Yi, et al.
Publicado: (2018)

Hepatocyte ALOXE3 is induced during adaptive fasting and enhances insulin sensitivity by activating hepatic PPARγ
por: Higgins, Cassandra B., et al.
Publicado: (2018)

Depletion of SENP1-mediated PPARγ SUMOylation exaggerates intermittent hypoxia-induced cognitive decline by aggravating microglia-mediated neuroinflammation
por: Wang, Hongwei, et al.
Publicado: (2021)

Lsd1 Restricts the Number of Germline Stem Cells by Regulating Multiple Targets in Escort Cells
por: Eliazer, Susan, et al.
Publicado: (2014)

HIV-1 Infection and the PPARγ-Dependent Control of Adipose Tissue Physiology
por: Giralt, Marta, et al.
Publicado: (2009)

GQ-16, a Novel Peroxisome Proliferator-activated Receptor γ (PPARγ) Ligand, Promotes Insulin Sensitization without Weight Gain
por: Amato, Angélica A., et al.
Publicado: (2012)

Swertiamarin: An Active Lead from Enicostemma littorale Regulates Hepatic and Adipose Tissue Gene Expression by Targeting PPAR-γ and Improves Insulin Sensitivity in Experimental NIDDM Rat Model
por: Patel, Tushar P., et al.
Publicado: (2013)

Regulation of Insulin Resistance and Adiponectin Signaling in Adipose Tissue by Liver X Receptor Activation Highlights a Cross-Talk with PPARγ
por: Zheng, Fenping, et al.
Publicado: (2014)

SENP3-Mediated PPARγ2 DeSUMOylation in BM-MSCs Potentiates Glucocorticoid-Induced Osteoporosis by Promoting Adipogenesis and Weakening Osteogenesis
por: Zhang, Yongxing, et al.
Publicado: (2021)

PPARγ in Neuroblastoma
por: Peri, Alessandro, et al.
Publicado: (2008)

Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases
por: Kulkarni, Ajit A., et al.
Publicado: (2012)

PPARγ is a major driver of the accumulation and phenotype of adipose-tissue T(reg) cells
por: Cipolletta, Daniela, et al.
Publicado: (2012)

Adipose tissue macrophages induce PPARγ-high FOXP3(+) regulatory T cells
por: Onodera, Toshiharu, et al.
Publicado: (2015)

Glucose intolerance after chronic stress is related with downregulated PPAR-γ in adipose tissue
por: Pereira, Vitor H., et al.
Publicado: (2016)

PRMT4 Facilitates White Adipose Tissue Browning and Thermogenesis by Methylating PPARγ
por: Zhong, Yi, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ujsolr2skrctssgmf27vaa9fm0