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The cytotoxic effect of diphtheria toxin on the actin cytoskeleton

Diphtheria toxin (DT) and its N-terminal fragment A (FA) catalyse the transfer of the ADP-ribose moiety of nicotinamide adenine dinucleotide (NAD) into a covalent linkage with eukaryotic elongation factor 2 (eEF2). DT-induced cytotoxicity is versatile, and it includes DNA cleavage and the depolymeri...

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Detalles Bibliográficos
Autores principales: Varol, Başak, Bektaş, Muhammet, Nurten, Rüstem, Bermek, Engin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SP Versita 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275567/
https://www.ncbi.nlm.nih.gov/pubmed/22139586
http://dx.doi.org/10.2478/s11658-011-0036-6