Identification of a non-canonical nuclear localization signal (NLS) in BRCA1 that could mediate nuclear localization of splice variants lacking the classical NLS

The breast cancer type 1 susceptibility gene (BRCA1) is a tumor suppressor gene, mutations or loss of which lead to genomic instability and breast cancer. BRCA1 protein is part of a large multi-protein complex involved in a variety of DNA repair and transcription regulatory functions. At least four...

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Detalles Bibliográficos
Autores principales: Korlimarla, Aruna, Bhandary, Lekhana, Prabhu, Jyothi S., Shankar, Hema, Sankaranarayanan, Hari, Kumar, Pravin, Remacle, Jose, Natarajan, Dipa, Sridhar, T. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SP Versita 2013
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275570/
https://www.ncbi.nlm.nih.gov/pubmed/23666596
http://dx.doi.org/10.2478/s11658-013-0088-x

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