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Cannabinoid-like anti-inflammatory compounds from flax fiber

Flax is a valuable source of fibers, linseed and oil. The compounds of the latter two products have already been widely examined and have been proven to possess many health-beneficial properties. In the course of analysis of fibers extract from previously generated transgenic plants overproducing ph...

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Autores principales: Styrczewska, Monika, Kulma, Anna, Ratajczak, Katarzyna, Amarowicz, Ryszard, Szopa, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SP Versita 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275574/
https://www.ncbi.nlm.nih.gov/pubmed/22706678
http://dx.doi.org/10.2478/s11658-012-0023-6
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author Styrczewska, Monika
Kulma, Anna
Ratajczak, Katarzyna
Amarowicz, Ryszard
Szopa, Jan
author_facet Styrczewska, Monika
Kulma, Anna
Ratajczak, Katarzyna
Amarowicz, Ryszard
Szopa, Jan
author_sort Styrczewska, Monika
collection PubMed
description Flax is a valuable source of fibers, linseed and oil. The compounds of the latter two products have already been widely examined and have been proven to possess many health-beneficial properties. In the course of analysis of fibers extract from previously generated transgenic plants overproducing phenylpropanoids a new terpenoid compound was discovered. The UV spectra and the retention time in UPLC analysis of this new compound reveal similarity to a cannabinoid-like compound, probably cannabidiol (CBD). This was confirmed by finding two ions at m/z 174.1 and 231.2 in mass spectra analysis. Further confirmation of the nature of the compound was based on a biological activity assay. It was found that the compound affects the expression of genes involved in inflammatory processes in mouse and human fibroblasts and likely the CBD from Cannabis sativa activates the specific peripheral cannabinoid receptor 2 (CB2) gene expression. Besides fibers, the compound was also found in all other flax tissues. It should be pointed out that the industrial process of fabric production does not affect CBD activity. The presented data suggest for the first time that flax products can be a source of biologically active cannabinoid-like compounds that are able to influence the cell immunological response. These findings might open up many new applications for medical flax products, especially for the fabric as a material for wound dressing with anti-inflammatory properties.
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spelling pubmed-62755742018-12-10 Cannabinoid-like anti-inflammatory compounds from flax fiber Styrczewska, Monika Kulma, Anna Ratajczak, Katarzyna Amarowicz, Ryszard Szopa, Jan Cell Mol Biol Lett Research Article Flax is a valuable source of fibers, linseed and oil. The compounds of the latter two products have already been widely examined and have been proven to possess many health-beneficial properties. In the course of analysis of fibers extract from previously generated transgenic plants overproducing phenylpropanoids a new terpenoid compound was discovered. The UV spectra and the retention time in UPLC analysis of this new compound reveal similarity to a cannabinoid-like compound, probably cannabidiol (CBD). This was confirmed by finding two ions at m/z 174.1 and 231.2 in mass spectra analysis. Further confirmation of the nature of the compound was based on a biological activity assay. It was found that the compound affects the expression of genes involved in inflammatory processes in mouse and human fibroblasts and likely the CBD from Cannabis sativa activates the specific peripheral cannabinoid receptor 2 (CB2) gene expression. Besides fibers, the compound was also found in all other flax tissues. It should be pointed out that the industrial process of fabric production does not affect CBD activity. The presented data suggest for the first time that flax products can be a source of biologically active cannabinoid-like compounds that are able to influence the cell immunological response. These findings might open up many new applications for medical flax products, especially for the fabric as a material for wound dressing with anti-inflammatory properties. SP Versita 2012-06-13 /pmc/articles/PMC6275574/ /pubmed/22706678 http://dx.doi.org/10.2478/s11658-012-0023-6 Text en © Versita Warsaw and Springer-Verlag Wien 2012
spellingShingle Research Article
Styrczewska, Monika
Kulma, Anna
Ratajczak, Katarzyna
Amarowicz, Ryszard
Szopa, Jan
Cannabinoid-like anti-inflammatory compounds from flax fiber
title Cannabinoid-like anti-inflammatory compounds from flax fiber
title_full Cannabinoid-like anti-inflammatory compounds from flax fiber
title_fullStr Cannabinoid-like anti-inflammatory compounds from flax fiber
title_full_unstemmed Cannabinoid-like anti-inflammatory compounds from flax fiber
title_short Cannabinoid-like anti-inflammatory compounds from flax fiber
title_sort cannabinoid-like anti-inflammatory compounds from flax fiber
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275574/
https://www.ncbi.nlm.nih.gov/pubmed/22706678
http://dx.doi.org/10.2478/s11658-012-0023-6
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