Pharmacological inhibition of GSK3 attenuates DNA damage-induced apoptosis via reduction of p53 mitochondrial translocation and Bax oligomerization in neuroblastoma SH-SY5Y CELLS

Glycogen synthase kinase-3 (GSK3) and p53 play crucial roles in the mitochondrial apoptotic pathway and are known to interact in the nucleus. However, it is not known if GSK3 has a regulatory role in the mitochondrial translocation of p53 that participates in apoptotic signaling following DNA damage...

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Detalles Bibliográficos
Autores principales: Ngok-Ngam, Patchara, Watcharasit, Piyajit, Thiantanawat, Apinya, Satayavivad, Jutamaad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SP Versita 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275584/
https://www.ncbi.nlm.nih.gov/pubmed/23161404
http://dx.doi.org/10.2478/s11658-012-0039-y

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