Cargando…

Antileukemic activity of combined epigenetic agents, DNMT inhibitors zebularine and RG108 with HDAC inhibitors, against promyelocytic leukemia HL-60 cells

DNMT inhibitors are promising new drugs for cancer therapies. In this study, we have observed the antileukemic action of two diverse DNMT inhibitors, the nucleoside agent zebularine and the non-nucleoside agent RG108, in human promyelocytic leukemia (PML) HL-60 cells. Zebularine but not RG108 caused...

Descripción completa

Detalles Bibliográficos
Autores principales:	Savickiene, Jurate, Treigyte, Grazina, Borutinskaite, Veronika-Viktorija, Navakauskiene, Ruta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SP Versita 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275587/ https://www.ncbi.nlm.nih.gov/pubmed/22820861 http://dx.doi.org/10.2478/s11658-012-0024-5

Ejemplares similares

Epigenetic changes during hematopoietic cell granulocytic differentiation – comparative analysis of primary CD34+ cells, KG1 myeloid cells and mature neutrophils
por: Navakauskienė, Rūta, et al.
Publicado: (2014)

Senescence-Associated Molecular and Epigenetic Alterations in Mesenchymal Stem Cell Cultures from Amniotic Fluid of Normal and Fetus-Affected Pregnancy
por: Savickienė, Jūratė, et al.
Publicado: (2016)

HDAC and HMT Inhibitors in Combination with Conventional Therapy: A Novel Treatment Option for Acute Promyelocytic Leukemia
por: Vitkevičienė, Aida, et al.
Publicado: (2019)

Corrigendum to “HDAC and HMT Inhibitors in Combination with Conventional Therapy: A Novel Treatment Option for Acute Promyelocytic Leukemia”
por: Vitkevičienė, Aida, et al.
Publicado: (2020)

The Histone Deacetylase Inhibitor BML-210 Influences Gene and Protein Expression in Human Promyelocytic Leukemia NB4 Cells via Epigenetic Reprogramming
por: Borutinskaitė, Veronika, et al.
Publicado: (2015)

Human Amniotic Fluid Mesenchymal Stem Cells from Second- and Third-Trimester Amniocentesis: Differentiation Potential, Molecular Signature, and Proteome Analysis
por: Savickiene, Jurate, et al.
Publicado: (2015)

Genetic and Epigenetic Signatures in Acute Promyelocytic Leukemia Treatment and Molecular Remission
por: Borutinskaitė, Veronika, et al.
Publicado: (2022)

Pharmaceutical Drug Metformin and MCL1 Inhibitor S63845 Exhibit Anticancer Activity in Myeloid Leukemia Cells via Redox Remodeling
por: Valiulienė, Giedrė, et al.
Publicado: (2021)

Comparative Proteomic Assessment of Normal vs. Polyhydramnios Amniotic Fluid Based on Computational Analysis
por: Navakauskienė, Rūta, et al.
Publicado: (2022)

DNA methylation enzyme inhibitor RG108 suppresses the radioresistance of esophageal cancer
por: Ou, Yao, et al.
Publicado: (2018)

HDAC Inhibitor LBH589 Suppresses the Proliferation but Enhances the Antileukemic Effect of Human γδT Cells
por: He, Ying, et al.
Publicado: (2020)

The DNA methylation inhibitor RG108 protects against noise-induced hearing loss
por: Zheng, Zhiwei, et al.
Publicado: (2021)

Epigenetic inhibitor zebularine activates ear pinna wound closure in the mouse
por: Sass, Piotr, et al.
Publicado: (2019)

6-Thioguanine and zebularine down-regulate DNMT1 and globally demethylate canine malignant lymphoid cells
por: Flesner, Brian K, et al.
Publicado: (2014)

Zebularine, a DNA Methylation Inhibitor, Activates Anthocyanin Accumulation in Grapevine Cells
por: Kong, Junhua, et al.
Publicado: (2022)

The Protective Effect of Zebularine, an Inhibitor of DNA Methyltransferase, on Renal Tubulointerstitial Inflammation and Fibrosis
por: Koh, Eun Sil, et al.
Publicado: (2022)

Examination of epigenetic inhibitor zebularine in treatment of skin wounds in healthy and diabetic mice
por: Sass, Piotr, et al.
Publicado: (2022)

Zebularine upregulates expression of CYP genes through inhibition of DNMT1 and PKR in HepG2 cells
por: Nakamura, Kazuaki, et al.
Publicado: (2017)

Effects of human placenta cryopreservation on molecular characteristics of placental mesenchymal stromal cells
por: Navakauskienė, Rūta, et al.
Publicado: (2023)

Potential Prognostic Markers for Relapsed/Refractory vs. Responsive Acute Myeloid Leukemia
por: Vitkevičienė, Aida, et al.
Publicado: (2022)

Effects of a novel DNA methyltransferase inhibitor Zebularine on human lens epithelial cells
por: Zhou, Peng, et al.
Publicado: (2012)

The DNA Methylation Inhibitor Zebularine Controls CD4(+) T Cell Mediated Intraocular Inflammation
por: Zou, Yanli, et al.
Publicado: (2019)

New Insights Into Pyridoxal Kinase Inhibitors and Their Antileukemic Effects
por: Banerjee, Pallabi, et al.
Publicado: (2023)

Small Molecule Treatments Improve Differentiation Potential of Human Amniotic Fluid Stem Cells
por: Zentelytė, Aistė, et al.
Publicado: (2021)

DNA Methyltransferase Inhibitor Zebularine Inhibits Human Hepatic Carcinoma Cells Proliferation and Induces Apoptosis
por: Nakamura, Kazuaki, et al.
Publicado: (2013)

Differential Mechanisms of Cell Death Induced by HDAC Inhibitor SAHA and MDM2 Inhibitor RG7388 in MCF-7 Cells
por: Natarajan, Umamaheswari, et al.
Publicado: (2018)

The HDAC and PI3K dual inhibitor CUDC-907 synergistically enhances the antileukemic activity of venetoclax in preclinical models of acute myeloid leukemia
por: Li, Xinyu, et al.
Publicado: (2020)

Antileukemic activity of the HSP70 inhibitor pifithrin-μ in acute leukemia
por: Kaiser, M, et al.
Publicado: (2011)

Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells
por: Etchin, J, et al.
Publicado: (2013)

Antileukemic activity of the VPS34-IN1 inhibitor in acute myeloid leukemia
por: Meunier, Godelieve, et al.
Publicado: (2020)

Belinostat, a potent HDACi, exerts antileukaemic effect in human acute promyelocytic leukaemia cells via chromatin remodelling
por: Valiuliene, Giedre, et al.
Publicado: (2015)

DNA Methyltransferase Inhibitor Zebularine Induces Human Cholangiocarcinoma Cell Death through Alteration of DNA Methylation Status
por: Nakamura, Kazuaki, et al.
Publicado: (2015)

Effect of Zebularine in Comparison to and in Combination with Trichostatin A on CIP/KIP Family (p21Cip1/Waf1/Sdi1, p27Kip1, and p57Kip2), DNMTs (DNMT1, DNMT3a, and DNMT3b), Class I HDACs (HDACs 1, 2, 3) and Class II HDACs (HDACs 4, 5, 6) Gene Expression, Cell Growth Inhibition and Apoptosis Induction in Colon Cancer LS 174T Cell Line
por: Sanaei, Masumeh, et al.
Publicado: (2020)

DNMT and HDAC inhibitors modulate MMP-9-dependent H3 N-terminal tail proteolysis and osteoclastogenesis
por: Shin, Yonghwan, et al.
Publicado: (2019)

Antileukemic properties of the kinase inhibitor OTSSP167 in T-cell acute lymphoblastic leukemia
por: Bridges, Cory Seth, et al.
Publicado: (2022)

HGG-30. BRAIN PENETRANT HDAC INHIBITOR RG2833 SYNERGIZES WITH LOMUSTINE AND RADIATION TO INDUCE DIPG CELL DEATH
por: Barnett, Katherine, et al.
Publicado: (2021)

Menstrual Blood-Derived Endometrial Stem Cells’ Impact for the Treatment Perspective of Female Infertility
por: Skliutė, Giedrė, et al.
Publicado: (2021)

Effects of DNMT1 and HDAC Inhibitors on Gene-Specific Methylation Reprogramming during Porcine Somatic Cell Nuclear Transfer
por: Xu, Weihua, et al.
Publicado: (2013)

Combining DNMT and HDAC6 inhibitors increases anti-tumor immune signaling and decreases tumor burden in ovarian cancer
por: Moufarrij, Sara, et al.
Publicado: (2020)

Human endometrium-derived mesenchymal stem/stromal cells application in endometrial-factor induced infertility
por: Bausyte, Raminta, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_sfmoo7bcg0gi7pq2coiu7tcsss