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Procaspase-9 is attached to the mitochondrial outer membrane in the early stages of apoptosis
Procaspase-9 is the zymogen form of one of the apoptosis initiators, caspase-9. Its cellular location may differ depending on the cell type; it is found throughout the cytosol, although some of it may be associated with the mitochondria. Procaspase-9 relocates from the cytosol to the mitochondria sh...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Versita
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275611/ https://www.ncbi.nlm.nih.gov/pubmed/17468838 http://dx.doi.org/10.2478/s11658-007-0020-3 |
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author | Milisav, Irina Šuput, Dušan |
author_facet | Milisav, Irina Šuput, Dušan |
author_sort | Milisav, Irina |
collection | PubMed |
description | Procaspase-9 is the zymogen form of one of the apoptosis initiators, caspase-9. Its cellular location may differ depending on the cell type; it is found throughout the cytosol, although some of it may be associated with the mitochondria. Procaspase-9 relocates from the cytosol to the mitochondria shortly after the triggering of apoptosis in rat hepatocytes. We investigated whether the mitochondrial protein import machineries import procaspase-9. The combined results of protein import analyses, mitochondrial fractionation and protease treatments of intact and swollen mitochondria imply that procaspase-9 attaches to the outer surface of the mitochondrial outer membrane. |
format | Online Article Text |
id | pubmed-6275611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Versita |
record_format | MEDLINE/PubMed |
spelling | pubmed-62756112018-12-10 Procaspase-9 is attached to the mitochondrial outer membrane in the early stages of apoptosis Milisav, Irina Šuput, Dušan Cell Mol Biol Lett Article Procaspase-9 is the zymogen form of one of the apoptosis initiators, caspase-9. Its cellular location may differ depending on the cell type; it is found throughout the cytosol, although some of it may be associated with the mitochondria. Procaspase-9 relocates from the cytosol to the mitochondria shortly after the triggering of apoptosis in rat hepatocytes. We investigated whether the mitochondrial protein import machineries import procaspase-9. The combined results of protein import analyses, mitochondrial fractionation and protease treatments of intact and swollen mitochondria imply that procaspase-9 attaches to the outer surface of the mitochondrial outer membrane. Versita 2007-04-28 /pmc/articles/PMC6275611/ /pubmed/17468838 http://dx.doi.org/10.2478/s11658-007-0020-3 Text en © University of Wrocław 2007 |
spellingShingle | Article Milisav, Irina Šuput, Dušan Procaspase-9 is attached to the mitochondrial outer membrane in the early stages of apoptosis |
title | Procaspase-9 is attached to the mitochondrial outer membrane in the early stages of apoptosis |
title_full | Procaspase-9 is attached to the mitochondrial outer membrane in the early stages of apoptosis |
title_fullStr | Procaspase-9 is attached to the mitochondrial outer membrane in the early stages of apoptosis |
title_full_unstemmed | Procaspase-9 is attached to the mitochondrial outer membrane in the early stages of apoptosis |
title_short | Procaspase-9 is attached to the mitochondrial outer membrane in the early stages of apoptosis |
title_sort | procaspase-9 is attached to the mitochondrial outer membrane in the early stages of apoptosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275611/ https://www.ncbi.nlm.nih.gov/pubmed/17468838 http://dx.doi.org/10.2478/s11658-007-0020-3 |
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