The influence of LTS-4, a saponoside from Lysimachia thyrsiflora L., on human skin fibroblasts and human melanoma cells

We investigated the effect of a triterpene saponoside from Lysimachia thyrsiflora L. upon the viability, proliferation, morphology and cell motility of human melanoma HTB-140 cells and human skin fibroblasts (HSFs). The compound, denoted LTS-4, decreased the viability and rate of cell growth of both...

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Autores principales: Galanty, Agnieszka, Michalik, Marta, Sędek, Łukasz, Podolak, Irma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SP Versita 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275633/
https://www.ncbi.nlm.nih.gov/pubmed/18553182
http://dx.doi.org/10.2478/s11658-008-0013-x
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author Galanty, Agnieszka
Michalik, Marta
Sędek, Łukasz
Podolak, Irma
author_facet Galanty, Agnieszka
Michalik, Marta
Sędek, Łukasz
Podolak, Irma
author_sort Galanty, Agnieszka
collection PubMed
description We investigated the effect of a triterpene saponoside from Lysimachia thyrsiflora L. upon the viability, proliferation, morphology and cell motility of human melanoma HTB-140 cells and human skin fibroblasts (HSFs). The compound, denoted LTS-4, decreased the viability and rate of cell growth of both cell types in a time-and dose-dependent manner, and proved cytotoxic against cancer cells at significantly lower concentrations than for fibroblasts. LTS-4 also affected the morphology of the examined cells, causing vacuolisation and actin cytoskeleton disintegration, and had an inhibitory effect on the tumour cell motility.
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spelling pubmed-62756332018-12-10 The influence of LTS-4, a saponoside from Lysimachia thyrsiflora L., on human skin fibroblasts and human melanoma cells Galanty, Agnieszka Michalik, Marta Sędek, Łukasz Podolak, Irma Cell Mol Biol Lett Research Article We investigated the effect of a triterpene saponoside from Lysimachia thyrsiflora L. upon the viability, proliferation, morphology and cell motility of human melanoma HTB-140 cells and human skin fibroblasts (HSFs). The compound, denoted LTS-4, decreased the viability and rate of cell growth of both cell types in a time-and dose-dependent manner, and proved cytotoxic against cancer cells at significantly lower concentrations than for fibroblasts. LTS-4 also affected the morphology of the examined cells, causing vacuolisation and actin cytoskeleton disintegration, and had an inhibitory effect on the tumour cell motility. SP Versita 2008-06-13 /pmc/articles/PMC6275633/ /pubmed/18553182 http://dx.doi.org/10.2478/s11658-008-0013-x Text en © © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2008
spellingShingle Research Article
Galanty, Agnieszka
Michalik, Marta
Sędek, Łukasz
Podolak, Irma
The influence of LTS-4, a saponoside from Lysimachia thyrsiflora L., on human skin fibroblasts and human melanoma cells
title The influence of LTS-4, a saponoside from Lysimachia thyrsiflora L., on human skin fibroblasts and human melanoma cells
title_full The influence of LTS-4, a saponoside from Lysimachia thyrsiflora L., on human skin fibroblasts and human melanoma cells
title_fullStr The influence of LTS-4, a saponoside from Lysimachia thyrsiflora L., on human skin fibroblasts and human melanoma cells
title_full_unstemmed The influence of LTS-4, a saponoside from Lysimachia thyrsiflora L., on human skin fibroblasts and human melanoma cells
title_short The influence of LTS-4, a saponoside from Lysimachia thyrsiflora L., on human skin fibroblasts and human melanoma cells
title_sort influence of lts-4, a saponoside from lysimachia thyrsiflora l., on human skin fibroblasts and human melanoma cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275633/
https://www.ncbi.nlm.nih.gov/pubmed/18553182
http://dx.doi.org/10.2478/s11658-008-0013-x
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