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Oncofetal antigen/immature laminin receptor protein in pregnancy and cancer
The 37-kDa immature laminin receptor protein (iLRP) is a speciesconserved, universal immunogenic protein that is expressed in all thus-far examined embryonic and early fetal cells of inbred and outbred rodents. It has also been identified in human concepti. It is altered through normal maturation pr...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Versita
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275639/ https://www.ncbi.nlm.nih.gov/pubmed/25082063 http://dx.doi.org/10.2478/s11658-014-0203-7 |
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author | Barsoum, Adel L. Schwarzenberger, Paul O. |
author_facet | Barsoum, Adel L. Schwarzenberger, Paul O. |
author_sort | Barsoum, Adel L. |
collection | PubMed |
description | The 37-kDa immature laminin receptor protein (iLRP) is a speciesconserved, universal immunogenic protein that is expressed in all thus-far examined embryonic and early fetal cells of inbred and outbred rodents. It has also been identified in human concepti. It is altered through normal maturation processes to become a non-immunogenic 67-kDa dimeric mature laminin receptor protein (mLRP) in mid-to late gestation in the mammalian fetus. This antigen ceases to be expressed as an active autoimmunogen in the full-term fetus and in the normal differentiating tissues and organs of the neonate or adult organism, apparently due to dimerization, but it is re-expressed as an immunogenic monomer in tumor cells. In this review, we highlight the known mechanisms of immune responses with particular emphasis on the possible role of the 37-kDa oncofetal antigen/immature laminin receptor (OFA/iLRP) in both pregnancy and cancer. |
format | Online Article Text |
id | pubmed-6275639 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Versita |
record_format | MEDLINE/PubMed |
spelling | pubmed-62756392018-12-10 Oncofetal antigen/immature laminin receptor protein in pregnancy and cancer Barsoum, Adel L. Schwarzenberger, Paul O. Cell Mol Biol Lett Mini Review The 37-kDa immature laminin receptor protein (iLRP) is a speciesconserved, universal immunogenic protein that is expressed in all thus-far examined embryonic and early fetal cells of inbred and outbred rodents. It has also been identified in human concepti. It is altered through normal maturation processes to become a non-immunogenic 67-kDa dimeric mature laminin receptor protein (mLRP) in mid-to late gestation in the mammalian fetus. This antigen ceases to be expressed as an active autoimmunogen in the full-term fetus and in the normal differentiating tissues and organs of the neonate or adult organism, apparently due to dimerization, but it is re-expressed as an immunogenic monomer in tumor cells. In this review, we highlight the known mechanisms of immune responses with particular emphasis on the possible role of the 37-kDa oncofetal antigen/immature laminin receptor (OFA/iLRP) in both pregnancy and cancer. Versita 2014-07-31 /pmc/articles/PMC6275639/ /pubmed/25082063 http://dx.doi.org/10.2478/s11658-014-0203-7 Text en © Versita Warsaw and Springer-Verlag Wien 2014 |
spellingShingle | Mini Review Barsoum, Adel L. Schwarzenberger, Paul O. Oncofetal antigen/immature laminin receptor protein in pregnancy and cancer |
title | Oncofetal antigen/immature laminin receptor protein in pregnancy and cancer |
title_full | Oncofetal antigen/immature laminin receptor protein in pregnancy and cancer |
title_fullStr | Oncofetal antigen/immature laminin receptor protein in pregnancy and cancer |
title_full_unstemmed | Oncofetal antigen/immature laminin receptor protein in pregnancy and cancer |
title_short | Oncofetal antigen/immature laminin receptor protein in pregnancy and cancer |
title_sort | oncofetal antigen/immature laminin receptor protein in pregnancy and cancer |
topic | Mini Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275639/ https://www.ncbi.nlm.nih.gov/pubmed/25082063 http://dx.doi.org/10.2478/s11658-014-0203-7 |
work_keys_str_mv | AT barsoumadell oncofetalantigenimmaturelamininreceptorproteininpregnancyandcancer AT schwarzenbergerpaulo oncofetalantigenimmaturelamininreceptorproteininpregnancyandcancer |